Evidence map›Paper›PMID 27020456›Full record

ArticleJournal of movement disorders2016

Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson's Disease.

Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of movement disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Prevalence and impact of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Pooled it
  2. Association of orthostatic hypotension with Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Association between ultra-short heart rate variability and risk of Parkinson's disease: a prospective cohort study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Autonomic Dysfunction in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joong-Seok KimDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Si-Hoon LeeDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yoon-Sang OhDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jeong-Wook ParkDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae-Young AnDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sung-Kyung ParkDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Si-Ryung HanDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kwang-Soo LeeDepartment of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic University of Korea · KRSeoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson's disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naïve and dopaminergic drug-treated groups.

methodsThis study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring. Autonomic function test results were evaluated among groups categorized by motor symptom severities (mild vs. moderate vs. severe) and treatment (drug-naïve or dopaminergic drug treatment).

resultsOrthostatic hypotension and supine hypertension were more frequent in patients with PD than in healthy controls. The frequencies of orthostatic hypotension, supine hypertension, nocturnal hypertension and non-dipping were not different among groups. Additionally, no significant differences were detected in supine BP, orthostatic BP change, nighttime BP, nocturnal BP dipping, or heart rate variabilities among groups.

conclusionsCardiovascular autonomic dysfunction is not confined to moderate to severe PD patients, and starts early in the course of the disease in a high proportion of PD patients. In addition, dopaminergic drug treatments do not affect cardiovascular autonomic function.

Indexed as

Autonomic dysfunctionCardiovascularDopaminergic treatmentParkinson’s diseaseSymptom severity

Identifiers

PMID27020456
PMCPMC4886202
OpenAlexW2315607473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.