ArticleJournal of biomedical optics2016
Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Assessment of cerebral autoregulation and cerebral perfusion in patients with sickle cell disease using frequency-domain near-infrared spectroscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Sensitivity of frequency-domain optical measurements to brain hemodynamics: simulations and human study of cerebral blood flow during hypercapnia.Biomedical optics express · 2021Article
- Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy.Frontiers in neuroscience · 2020Review
- Dynamic cerebral autoregulation estimates derived from near infrared spectroscopy and transcranial Doppler are similar after correction for transit time and blood flow and blood volume oscillations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
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- Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Broadband optical mammography instrument for depth-resolved imaging and local dynamic measurements.The Review of scientific instruments · 2016Article
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4 authors.
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Abstract
We present a near-infrared spectroscopy (NIRS) study of local hemodynamics in the breast and the brain (prefrontal cortex) of healthy volunteers in a protocol involving periodic perturbations to the systemic arterial blood pressure. These periodic perturbations were achieved by cyclic inflation (to a pressure of 200 mmHg) and deflation (at frequencies of 0.046, 0.056, 0.063, 0.071, and 0.083 Hz) of two pneumatic cuffs wrapped around the subject’s thighs. As a result of these systemic perturbations, the concentrations of deoxy- and oxyhemoglobin in tissue (D and O , respectively) oscillate at the set frequency. We found that the oscillations of D and O in breast tissue are in-phase at all frequencies considered, a result that we attribute to dominant contributions from blood volume oscillations. In contrast, D and O oscillations in brain tissue feature a frequency-dependent phase difference, which we attribute to significant contributions from cerebral blood flow oscillations. Frequency-resolved measurements of D and O oscillations are exploited by the technique of coherent hemodynamics spectroscopy for the assessment of cerebrovascular parameters and cerebral autoregulation. We show the relevant physiological information content of NIRS measurements of oscillatory hemodynamics, which have qualitatively distinct features in the healthy breast and healthy brain.
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