Evidence map›Paper›PMID 27019754›Full record

ArticleNeural plasticity2016

Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users.

Samantha J Broyd, Lisa-marie Greenwood, Hendrika H van Hell, Rodney J Croft, Hannah Coyle, Ben Lee-Bates, Juanita Todd, Stuart J Johnstone, Patricia T Michie, Nadia Solowij

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Acute effects of ΔPsychopharmacology · 2022
    Trial
  2. Review
  3. Review
  4. Aberrant inhibitory processing in the somatosensory cortices of cannabis-users.Journal of psychopharmacology (Oxford, England) · 2021
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samantha J BroydSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Lisa-marie GreenwoodSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Hendrika H van HellSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia.
Rodney J CroftSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia; Centre for Health Initiatives, University of Wollongong, Wollongong, NSW 2522, Australia.
Hannah CoyleSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia.
Ben Lee-BatesSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia.
Juanita ToddSchool of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, NSW 2308, Australia; Schizophrenia Research Institute, Sydney, NSW 2021, Australia.
Stuart J JohnstoneSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia.
Patricia T MichieSchool of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, NSW 2308, Australia; Schizophrenia Research Institute, Sydney, NSW 2021, Australia.
Nadia SolowijSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia; Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia; Schizophrenia Research Institute, Sydney, NSW 2021, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations. We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users. This study investigated the extent of brain functional recovery (indexed by MMN and P50) in chronic users after cessation of use. Eighteen ex-users (median 13.5 years prior regular use; median 3.5 years abstinence) and 18 nonusers completed (1) a multifeature oddball task with duration, frequency, and intensity deviants and (2) a P50 paired-click paradigm. Trend level smaller duration MMN amplitude and larger P50 ratios (indicative of poorer sensory gating) were observed in ex-users compared to controls. Poorer P50 gating correlated with prior duration of cannabis use. Duration of abstinence was positively correlated with duration MMN amplitude, even after controlling for age and duration of cannabis use. Impaired sensory gating and attenuated MMN amplitude tended to persist in ex-users after prolonged cessation of use, suggesting a lack of full recovery. An association with prolonged duration of prior cannabis use may indicate persistent cannabis-related alterations to P50 sensory gating. Greater reductions in MMN amplitude with increasing abstinence (positive correlation) may be related to either self-medication or an accelerated aging process.

Indexed as

Evoked PotentialsSensory GatingAcoustic StimulationAdultCerebral CortexElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleMarijuana SmokingMiddle AgedYoung Adult

Identifiers

PMID27019754
PMCPMC4785272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.