Evidence map›Paper›PMID 27019745›Full record

ArticleBMJ innovations2016

Conducting a fully mobile and randomised clinical trial for depression: access, engagement and expense.

Joaquin A Anguera, Joshua T Jordan, Diego Castaneda, Adam Gazzaley, Patricia A Areán

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ innovations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00540865 (Case Management and Problem Solving Therapy for Depressed, Homebound, Low-Income Elders), which is not on this map. Cited by 109 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 9 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00540865 nacompletednot on this map

Case Management and Problem Solving Therapy for Depressed, Homebound, Low-Income Elders

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2007 to 2013Enrolled187ConditionsDepressionArmsProblem-solving therapy (PST), Case management (CM)
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 9 syntheses or guidelines pooled it, 192 citations in OpenAlex.

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  11. A pilot study of a targeted cognitive intervention for cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  14. Recruiting for a Randomized Clinical Trial for Late-Life Depression During COVID-19: Outcomes of Provider Referrals Versus Facebook Self-Referrals.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joaquin A AngueraDepartments of Neurology and Psychiatry , University of California , San Francisco, California , USA.ORCID 0000-0002-7216-0674
Joshua T JordanDepartments of Neurology and Psychiatry , University of California , San Francisco, California , USA.
Diego CastanedaDepartments of Neurology and Psychiatry , University of California , San Francisco, California , USA.
Adam GazzaleyDepartments of Neurology and Psychiatry , University of California , San Francisco, California , USA.
Patricia A AreánDepartment of Psychiatry and Behavioral Sciences , University of Washington , Seattle, Washington , USA.
University of California, San Francisco · USUniversity of Washington · US

Funding

CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
Treating Depression in Low-Income Elderly with CIND/AMCIK24MH074717 · NIMH · UNIVERSITY OF WASHINGTON · PI AREAN, PATRICIA A. · 2005 to 2016
$1.7M
Can Metal Health Apps Work in the Real World? A Feasibility Pilot StudyR34MH100466 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANGUERA, JOAQUIN A, GAZZALEY, ADAM H · 2013 to 2015
$818k
NIMH NIH HHS K24 MH074717NIMH NIH HHS R34 MH100466NIMH NIH HHS T32 MH018261
6 · The paper itself

Abstract

importanceAdvances in mobile technology have resulted in federal and industry-level initiatives to facilitate large-scale clinical research using smart devices. Although the benefits of technology to expand data collection are obvious, assumptions about the reach of mobile research methods (

objectiveTo assess the feasibility of a fully mobile randomised controlled trial using assessments and treatments delivered entirely through mobile devices to depressed individuals.

designUsing a web-based research portal, adult participants with depression who also owned a smart device were screened, consented and randomised to 1 of 3 mental health apps for treatment. Assessments of self-reported mood and cognitive function were conducted at baseline, 4, 8 and 12 weeks. Physical and social activity was monitored daily using passively collected phone use data. All treatment and assessment tools were housed on each participant's smart phone or tablet.

interventionsA cognitive training application, an application based on problem-solving therapy, and a mobile-sensing application promoting daily activities.

resultsCONCLUSIONS AND RELEVANCE: These findings suggest that mobile randomised control trials can recruit large numbers of participants in a short period of time and with minimal cost, but study engagement remains challenging. TRIAL REGISTRATION NUMBER: NCT00540865.

Indexed as

AccessiblemHealthPsychiatry

Identifiers

PMID27019745
PMCPMC4789688
OpenAlexW2261303017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.