Evidence map›Paper›PMID 27019702›Full record

ArticleRSC advances2015

Trivalent Gd-DOTA reagents for modification of proteins.

Martin J Fisher, Daniel J Williamson, George M Burslem, Jeffrey P Plante, Iain W Manfield, Christian Tiede, James R Ault, Peter G Stockley, Sven Plein, Azhar Maqbool and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Martin J FisherSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
Daniel J WilliamsonSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
George M BurslemSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
Jeffrey P PlanteSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
Iain W ManfieldAstbury Centre for Structural Molecular Biology , University of Leeds , UK ; School of Molecular and Cellular Biology , University of Leeds , UK.
Christian TiedeAstbury Centre for Structural Molecular Biology , University of Leeds , UK ; School of Molecular and Cellular Biology , University of Leeds , UK.
James R AultAstbury Centre for Structural Molecular Biology , University of Leeds , UK ; School of Molecular and Cellular Biology , University of Leeds , UK.
Peter G StockleyAstbury Centre for Structural Molecular Biology , University of Leeds , UK ; School of Molecular and Cellular Biology , University of Leeds , UK.
Sven PleinLeeds Institute of Cardiovascular and Metabolic Medicine , University of Leeds , UK ; Multidisciplinary Cardiovascular Research Centre , University of Leeds , UK.
Azhar MaqboolLeeds Institute of Cardiovascular and Metabolic Medicine , University of Leeds , UK ; Multidisciplinary Cardiovascular Research Centre , University of Leeds , UK.
Darren C TomlinsonAstbury Centre for Structural Molecular Biology , University of Leeds , UK ; School of Molecular and Cellular Biology , University of Leeds , UK.
Richard FosterSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK ; Multidisciplinary Cardiovascular Research Centre , University of Leeds , UK.
Stuart L WarrinerSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK.
Robin S BonSchool of Chemistry , University of Leeds , LS2 9JT , UK . Email: r.bon@leeds.ac.uk; Astbury Centre for Structural Molecular Biology , University of Leeds , UK ; Leeds Institute of Cardiovascular and Metabolic Medicine , University of Leeds , UK ; Multidisciplinary Cardiovascular Research Centre , University of Leeds , UK.

Funding

British Heart Foundation NH/12/1/29382
6 · The paper itself

Abstract

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (

Identifiers

PMID27019702
PMCPMC4786947

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.