ArticleCurrent respiratory medicine reviews
Outcome Measures for Clinical Trials in Interstitial Lung Diseases.
Article in Current respiratory medicine reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Real-world experience: correlation of three dyspnoea questionnaires with measures of disease severity and progression in patients with interstitial lung diseases.BMJ open respiratory research · 2026Article
- AI-Based HRCT Quantification in Connective Tissue Disease-Associated Interstitial Lung Disease.Diagnostics (Basel, Switzerland) · 2025Article
- Examining Cough's Role and Relief Strategies in Interstitial Lung Disease.Journal of clinical medicine · 2025Review
- Natural disease course of chronic visceral acid sphingomyelinase deficiency in adults: A first step toward treatment criteria.Journal of inherited metabolic disease · 2025Article
- Assessment of health-related quality of life in individuals with interstitial lung diseases in a tertiary care hospital in south India.The Indian journal of medical research · 2024Article
- The modified Medical Research Council scale misclassifies exertional breathlessness among people referred for exercise testing.ERJ open research · 2023Article
- Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries.Antioxidants (Basel, Switzerland) · 2023Review
- A comprehensive framework for navigating patient care in systemic sclerosis: A global response to the need for improving the practice of diagnostic and preventive strategies in SSc.Best practice & research. Clinical rheumatology · 2021Review
- Feasibility of cardiopulmonary exercise testing in interstitial lung disease: the PETFIB study.BMJ open respiratory research · 2021Article
- Establishing content-validity of a disease-specific health-related quality of life instrument for patients with chronic hypersensitivity pneumonitis.Journal of patient-reported outcomes · 2021Article
- Health Related Quality of Life in Interstitial Lung Disease: Can We Use the Same Concepts Around the World?Frontiers in medicine · 2021Review
- Autologous stem-cell transplantation in systemic sclerosis-associated interstitial lung disease: early action in selected patients rather than escalation therapy for all.Therapeutic advances in musculoskeletal disease · 2021Review
- Antitussive Effect of a Chest Band in Patients with Interstitial Lung Disease: The Preliminary Results from a Pre-post Intervention Study.Internal medicine (Tokyo, Japan) · 2021Article
- Patient and Physician Perspectives on Systemic Sclerosis-Associated Interstitial Lung Disease.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2020Article
- Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study.BMC pulmonary medicine · 2019Article
- Patients' perceptions and patient-reported outcomes in progressive-fibrosing interstitial lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Performance of Forced Vital Capacity and Lung Diffusion Cutpoints for Associated Radiographic Interstitial Lung Disease in Systemic Sclerosis.The Journal of rheumatology · 2018Article
- Mechanisms of exercise limitation in patients with chronic hypersensitivity pneumonitis.ERJ open research · 2018Article
- A comparison trial of eight weeks versus twelve weeks of exercise program in interstitial lung diseases.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Evaluating disease severity in idiopathic pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 5 countries.
Funding
Abstract
The chronic fibrosing idiopathic interstitial pneumonias (IIPs) are a group of heterogeneous pulmonary parenchymal disorders described by radiologic and histological patterns termed usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP). These include idiopathic pulmonary fibrosis (IPF) and those related to connective tissue disease (CTD) and are associated with substantial morbidity and mortality. Beyond the importance of establishing an appropriate diagnosis, designing optimal clinical trials for IIPs has been fraught with difficulties in consistency of clinical endpoints making power analyses, and the establishment of efficacy and interpretation of results across trials challenging. Preliminary recommendations, developed by rigorous consensus methods, proposed a minimum set of outcome measures, a 'core set', to be incorporated into future clinical trials (Saketkoo et al, THORAX. 2014.). This paper sets out to examine the candidate instruments for each domain (Dyspnea, Cough, Health Related Quality of Life, Imaging, Lung Physiology and Function, Mortality). Candidate measures that were not selected as well as measures that were not available for examination at the time of the consensus process will also be discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.