ArticlePharmacognosy magazine
Comparation of Hypolipidemic and Antioxidant Effects of Aqueous and Ethanol Extracts of Crataegus pinnatifida Fruit in High-Fat Emulsion-Induced Hyperlipidemia Rats.
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 22 citations in OpenAlex.
- Hawthorn Polysaccharides Relieve High-Fat Blood Disease in Mice by Improving Intestinal Flora and Promoting Lipid Metabolism.Foods (Basel, Switzerland) · 2026Article
- Hawthorn (Molecules (Basel, Switzerland) · 2026Review
- The Hypolipidemic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Lipid-lowering and antioxidative effects ofRSC advances · 2019Article
- Enhancement of the antioxidant and hypolipidemic activities of Puerariae radix by fermentation withFood science and biotechnology · 2019Article
- The potential neuritogenic activity of aqueous extracts fromFood science and biotechnology · 2017Article
- Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action.Frontiers in pharmacology · 2016Review
- Evaluation of Hypolipidemic and Antioxidant Effects in Phenolrich Fraction ofPharmacognosy magazineArticle
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6 authors at 1 institution in 1 country.
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Abstract
backgroundHawthorn (Crataegus pinnatifida) is a Chinese medicinal plant traditionally used in the treatment of hyperlipidemia. Recently, studies indicated free radical scavenging was one of the major pathways to alleviate hyperlipidemia. Moreover, hawthorn fruit is a rich source of phenols, which quench free radical and attenuate hyperlipidemia. However, the phenols vary with processing methods, especially solvent type.
objectiveOur aim was to compare hypolipidemic and antioxidant effects of aqueous and ethanol extracts of hawthorn fruit in hyperlipidemia rats. MATERIALS AND
methodsAfter a 4-week treatment of high-fat emulsion, lipid profile levels and antioxidant levels of two extracts were determined using commercial analysis. Total phenols content in the extract of hawthorn fruit was determined colorimetrically by the Folin-Ciocalteu method.
resultsBoth ethanol and aqueous extracts of hawthorn fruit possessed hypolipidemic and antioxidant activities. Simultaneously, stronger activities were observed in ethanol extract. Besides, total phenols content in ethanol extract from the same quality of hawthorn fruit was 3.9 times more than that in aqueous extract.
conclusionThe obvious difference of hypolipidemic and antioxidant effects between ethanol extract and aqueous extract of hawthorn fruit was probably due to the presence of total phenols content, under the influence of extraction solvent. SUMMARY: Ethanol extract of hawthorn fruit exhibited more favorable hypolipidemic and antioxidant effects than aqueous extract. The higher effects could be due to the higher content of total phenols that varies with extraction solvent. Abbreviations used: TC: Total cholesterol, TG: Triglyceride, LDL-C: Low-density lipoprotein cholesterol, HDL-C: High-density lipoprotein cholesterol, GSH-Px: Glutathione peroxidase, SOD: Superoxide dismutase, MDA: Malondialdehyde, CAT: Catalase, NO: Nitric oxide, NOS: Nitric oxide synthase, SR-BI: Scavenger receptor Class B Type I.
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