ArticlePloS one2016
A Study of the Infant Nasal Microbiome Development over the First Year of Life and in Relation to Their Primary Adult Caregivers Using cpn60 Universal Target (UT) as a Phylogenetic Marker.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- The neonatal and maternal nasal microbiomes are compositionally diverse and functionally distinct within 24 hours of birth.Frontiers in cellular and infection microbiology · 2026Article
- Article
- Association of Neonatal and Maternal Nasal Microbiome Among Neonates in the Intensive Care Unit.Open forum infectious diseases · 2024Article
- Upper respiratory microbial communities of healthy populations are shaped by niche and age.Microbiome · 2024Article
- Metabolic capabilities are highly conserved among human nasal-associatedbioRxiv : the preprint server for biology · 2024Article
- Upper respiratory microbial communities of healthy populations are shaped by niche and age.bioRxiv : the preprint server for biology · 2024Article
- Rapid and accurate taxonomic classification of cpn60 amplicon sequence variants.ISME communications · 2023Article
- Dysbiotic lung microbial communities of neonates from allergic mothers confer neonate responsiveness to suboptimal allergen.Frontiers in allergy · 2023Article
- Hybrid use of Raman spectroscopy and artificial neural networks to discriminate Mycobacterium bovis BCG and other Mycobacteriales.PloS one · 2023Article
- Factors Limiting the Translatability of Rodent Model-Based Intranasal Vaccine Research to Humans.AAPS PharmSciTech · 2022Review
- The nasal microbiome of predicting bronchopulmonary dysplasia in preterm infants.Scientific reports · 2022Observational
- Article
- Low Diversity in Nasal Microbiome Associated WithOpen forum infectious diseases · 2021Article
- CaptureSeq: Hybridization-Based Enrichment ofMicroorganisms · 2021Article
- Friend or Foe: Interbacterial Competition in the Nasal Cavity.Journal of bacteriology · 2021Review
- Composition of nasal bacterial community and its seasonal variation in health care workers stationed in a clinical research laboratory.PloS one · 2021Article
- Determinants of Staphylococcus aureus carriage in the developing infant nasal microbiome.Genome biology · 2020Article
- Association of chronic rhinosinusitis with high microbiome dissimilarity among different patients and within individuals over time.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Article
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Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas the infant gut microbiome is the subject of intense study, relatively little is known regarding the nares microbiome in newborns and during early life. This study aimed to survey the typical composition and diversity of human anterior nare microflora for developing infants over time, and to explore how these correlate to their primary caregivers. Single nare swabs were collected at five time points over a one-year period for each subject from infant-caregiver pairs. Our study comprised of 50 infants (recruited at 2 weeks, post delivery) and their 50 primary caregivers. Applying the chaperonin-60 (cpn60) universal target (UT) amplicon as our molecular barcoding marker to census survey the microbial communities, we longitudinally surveyed infant nares microbiota at 5 time points over the course of the first year of life. The inter- and intra-subject diversity was catalogued and compared, both longitudinally and relative to their adult primary caregivers. Although within-subject variability over time and inter-subject variability were both observed, the assessment detected only one or two predominant genera for individual infant samples, belonging mainly to phyla Actinobacteria, Firmicutes, and Proteobacteria. Consistent with previously observed microbial population dynamics in other body sites, the diversity of nares microflora increased over the first year of life and infants showed differential operational taxonomic units (OTUs) relative to their matched primary caregiver. The collected evidence also support that both temporal and seasonal changes occur with respect to carriage of potentially pathogenic bacteria (PPBs), which may influence host predisposition to infection. This pilot study surveying paired infant/caregiver nare microbiomes provides novel longitudinal diversity information that is pertinent to better understanding nare microbiome development in infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.