ArticleEpigenetics2018
Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.
Article in Epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation risk score for type 2 diabetes is associated with gestational diabetes.Cardiovascular diabetology · 2024Pooled it
- Association of prenatal glycemic marker cumulative exposure with placental DNA methylation change.The Journal of clinical endocrinology and metabolism · 2026Article
- Article
- Deciphering DNA Methylation in Gestational Diabetes Mellitus: Epigenetic Regulation and Potential Clinical Applications.International journal of molecular sciences · 2024Review
- The association between dietary, physical activity and the DNA methylation of PPARGC1A, HLA-DQA1 and ADCY3 in pregnant women with gestational diabetes mellitus: a nest case-control study.BMC pregnancy and childbirth · 2024Article
- Comprehensive pan-cancer analysis reveals that C5orf34 regulates the proliferation and mortality of lung cancer.Functional & integrative genomics · 2024Article
- Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes.Metabolites · 2024Review
- Gestational diabetes mellitus: genetic factors, epigenetic alterations, and microbial composition.Acta diabetologica · 2024Review
- Article
- Epigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes.Epigenetics · 2023Article
- Article
- Epigenetic marks associated with gestational diabetes mellitus across two time points during pregnancy.Clinical epigenetics · 2023Article
- Genetics and Epigenetics: Implications for the Life Course of Gestational Diabetes.International journal of molecular sciences · 2023Review
- Maternal and Placental DNA Methylation Changes Associated with the Pathogenesis of Gestational Diabetes Mellitus.Nutrients · 2022Review
- Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event.International journal of molecular sciences · 2022Review
- DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances.The Journal of clinical endocrinology and metabolism · 2022Observational
- Epigenetic Links between Microbiota and Gestational Diabetes.International journal of molecular sciences · 2022Review
- The role of maternal DNA methylation in pregnancies complicated by gestational diabetes.Frontiers in clinical diabetes and healthcare · 2022Review
- Comparison of DNA Methylation Changes Between the Gestation Period and the After-Delivery State: A Pilot Study of 10 Women.Frontiers in nutrition · 2022Article
- DNA methylation analysis of cord blood samples in neonates born to gestational diabetes mothers diagnosed before 24 gestational weeks.BMJ open diabetes research & care · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to determine changes to the epigenome in a unique cohort of maternal blood DNA from 11 pregnant women prior to GDM development relative to matched controls. Hierarchical clustering segregated the samples into 2 distinct clusters comprising GDM and healthy pregnancies. Screening identified 100 CpGs with a mean β-value difference of ≥0.2 between cases and controls. Using stringent criteria, 5 CpGs (within COPS8, PIK3R5, HAAO, CCDC124, and C5orf34 genes) demonstrated potentials to be clinical biomarkers as revealed by differential methylation in 8 of 11 women who developed GDM relative to matched controls. We identified, for the first time, maternal methylation changes prior to the onset of GDM that may prove useful as biomarkers for early therapeutic intervention.
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