ArticleNature neuroscience2016
Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 1 of them a synthesis that pooled it.
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Who cites it
182 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses.bioRxiv : the preprint server for biology · 2026Article
- The tectal melanocortin system modulates energy-dependent visual avoidance behavior in zebrafish.iScience · 2026Article
- Article
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- Glycogen drives the sensory activation of POMC neurons.Nature metabolism · 2026Article
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents.Science advances · 2026Article
- Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.bioRxiv : the preprint server for biology · 2026Article
- The mitigation of activity-based anorexia by obese adipose tissue transplant is abolished by neonatal AgRP neuron ablation.Translational psychiatry · 2026Article
- Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans.Nature communications · 2026Article
- Sex-specific differences in mediobasal hypothalamus in response to nutritional states.Nature communications · 2026Article
- Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling.Cell discovery · 2026Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice.Acta neuropathologica communications · 2025Article
- Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum.Neuron · 2025Article
- Article
122 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
In the face of starvation, animals will engage in high-risk behaviors that would normally be considered maladaptive. Starving rodents, for example, will forage in areas that are more susceptible to predators and will also modulate aggressive behavior within a territory of limited or depleted nutrients. The neural basis of these adaptive behaviors likely involves circuits that link innate feeding, aggression and fear. Hypothalamic agouti-related peptide (AgRP)-expressing neurons are critically important for driving feeding and project axons to brain regions implicated in aggression and fear. Using circuit-mapping techniques in mice, we define a disynaptic network originating from a subset of AgRP neurons that project to the medial nucleus of the amygdala and then to the principal bed nucleus of the stria terminalis, which suppresses territorial aggression and reduces contextual fear. We propose that AgRP neurons serve as a master switch capable of coordinating behavioral decisions relative to internal state and environmental cues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.