ArticleNature structural & molecular biology2016
Universality of supersaturation in protein-fiber formation.
Article in Nature structural & molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- In Silico Post-screening of Anti-polymerization Agents to Treat Sickle Cell Disease.bioRxiv : the preprint server for biology · 2025Article
- Generating the polymorph landscapes of amyloid fibrils using AI: RibbonFold.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hyperactive deoxy-PIEZO1 shapes the circulatory life cycle of irreversibly sickled cells.Biophysical journal · 2025Article
- On the reversibility of amyloid fibril formation.Biophysics reviews · 2025Review
- Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Impact of hemoglobin biophysical studies on molecular pathogenesis and drug therapy for sickle cell disease.Molecular aspects of medicine · 2022Review
- Caffeic acid: an antioxidant with novel antisickling properties.FEBS open bio · 2021Article
- Article
- MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding.Biophysical journal · 2021Article
- Research in Sickle Cell Disease: From Bedside to Bench to Bedside.HemaSphere · 2021Review
- Does liquid-liquid phase separation drive peptide folding?Chemical science · 2020Article
- Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Hemoglobin S polymerization and sickle cell disease: A retrospective on the occasion of the 70th anniversary of Pauling's Science paper.American journal of hematology · 2020Review
- Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies.Science advances · 2019Article
- Substitutions in the β subunits of sickle-cell hemoglobin improve oxidative stability and increase the delay time of sickle-cell fiber formation.The Journal of biological chemistry · 2019Article
- Theoretical Simulation of Red Cell Sickling Upon Deoxygenation Based on the Physical Chemistry of Sickle Hemoglobin Fiber Formation.The journal of physical chemistry. B · 2018Article
- Surveying the Energy Landscapes of Aβ Fibril Polymorphism.The journal of physical chemistry. B · 2018Article
- Solid nuclei and liquid droplets: A parallel treatment for 3 phase systems.Protein science : a publication of the Protein Society · 2018Article
- Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.Metallomics : integrated biometal science · 2017Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The thermodynamics and kinetics of the aggregation of sickle-cell hemoglobin into fibers have been studied in great detail under a wide range of solution conditions. The stability of the fiber is measured by the solubility; the kinetics is characterized by a delay before the appearance of fibers. A review of data in the literature shows that there is no correlation of the delay time with fiber stability and only a weak correlation with the initial protein concentration. There is, however, a striking collapse of all the data onto a single universal curve when the delay time is plotted versus the supersaturation, which is the ratio of the initial protein concentration to the solubility, expressed as activities. Collapse onto the same universal curve is also obtained when using delay times calculated from the double-nucleation theoretical model.
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Registered trials
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