SynthesisPlastic and reconstructive surgery2016
Ibuprofen May Not Increase Bleeding Risk in Plastic Surgery: A Systematic Review and Meta-Analysis.
Synthesis in Plastic and reconstructive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Effect of perioperative intravenous ibuprofen versus acetaminophen on postoperative opioid consumption and pain after general anesthesia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.Korean journal of anesthesiology · 2024Pooled it
- Single-dose intravenous ibuprofen for acute postoperative pain in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period.Journal of the American College of Surgeons · 2021Pooled it
- American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Opioid Minimization in Opioid-Naïve Patients.Anesthesia and analgesia · 2019Guideline
- The comparison of single-dose preemptive intravenous ibuprofen and paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Trial
- Pilot Study: Evaluation of the Feasibility of a Multimodal Analgesia Protocol for Primary Breast Augmentation Patients.Plastic and reconstructive surgery. Global open · 2026Article
- Association Between Nonsteroidal Anti-inflammatory Drugs Use and Surgical Outcomes Following Posterior Lumbar Fusion: A Medical Claims Database Analysis.International journal of spine surgery · 2025Article
- A Review of Current Literature of Interest to the Office-Based Anesthesiologist.Anesthesia progress · 2024Article
- Minimizing Narcotic Use in Rhinoplasty: An Updated Narrative Review and Protocol.Life (Basel, Switzerland) · 2024Review
- The Multifaceted Effects of Non-Steroidal and Non-Opioid Anti-Inflammatory and Analgesic Drugs on Platelets: Current Knowledge, Limitations, and Future Perspectives.Pharmaceuticals (Basel, Switzerland) · 2024Review
- A Comparison of Multimodal Analgesic Regimens for Opioid Reduction in Elective Plastic Surgery: A Randomized Study.Plastic and reconstructive surgery. Global open · 2023Article
- Comparative Evaluation of Postoperative Pain Scores and Opioid Consumption in Septorhinoplasty After Administration of Single-Dose Preemptive Paracetamol and Ibuprofen: A Randomized Controlled Trial.International archives of otorhinolaryngology · 2023Article
- Can Anti-inflammatory Drugs used in Plastic Surgery Procedures Increase the Risk of Hematoma?Aesthetic plastic surgery · 2023Review
- Opioid-sparing Strategies in Alloplastic Breast Reconstruction: A Systematic Review.Plastic and reconstructive surgery. Global open · 2021Article
- Needle EMG induced muscle bleeding complication after guideline approved discontinuation of anticoagulation.Clinical neurophysiology practice · 2021Article
- Opioid Prescribing and Use Patterns in Postsurgical Facial Trauma Patients.Plastic and reconstructive surgery · 2020Article
- Safe anesthesia for office-based plastic surgery: Proceedings from the PRS Korea 2018 meeting in Seoul, Korea.Archives of plastic surgery · 2019Article
- Persistent Opioid Use and High-Risk Prescribing in Body Contouring Patients.Plastic and reconstructive surgery · 2019Article
- Postoperative Ketorolac in Breast and Body Contouring Procedures: A Nationwide Claims Analysis.Plastic and reconstructive surgery · 2018Article
- Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis.Burns & trauma · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNonsteroidal antiinflammatory drugs such as ibuprofen are common medications with multiple useful effects, including pain relief and reduction of inflammation. However, surgeons commonly withhold all nonsteroidal antiinflammatory drugs perioperatively because of bleeding concerns. However, not all nonsteroidal antiinflammatory drugs irreversibly block platelet function. The authors hypothesized that the use of ibuprofen would have no effect on postoperative bleeding in plastic surgery patients.
methodsA literature review was performed using MEDLINE (PubMed), EMBASE, and the Cochrane Collaboration Library for primary research articles on ibuprofen and bleeding. Inclusion criteria were primary journal articles examining treatment of acute postoperative pain based on any modality. Data related to pain assessment, postoperative recovery, and complications were extracted. Bias assessment and meta-analysis were performed.
resultsA total of 881 publications were reviewed. Four primary randomized controlled trials were selected for full analysis. Articles were of high quality by bias assessment. No significant difference was noted regarding bleeding events (p = 0.32), and pain control was noted to be equivalent.
conclusionsIbuprofen is a useful medication in the setting of surgery, with multiple beneficial effects. This meta-analysis represents a small set of high-quality studies suggesting that ibuprofen provides pain control equivalent to narcotics. Importantly, ibuprofen was not associated with an increased risk of bleeding. Further large studies will be necessary to elucidate this issue further, but ibuprofen is a safe postoperative analgesic in patients undergoing common plastic surgery soft-tissue procedures. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.