ArticleEpidemiology and psychiatric sciences2017
A comparison of the cumulative incidence and early risk factors for psychotic disorder in young adults in the Northern Finland Birth Cohorts 1966 and 1986.
Article in Epidemiology and psychiatric sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Psychiatric research in the Northern Finland Birth Cohort 1986 - a systematic review.International journal of circumpolar health · 2019Pooled it
- Incidence of psychotic disorders by birth cohort: a population-based cohort study in Ontario, Canada.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Attention deficit hyperactivity and oppositional defiant disorder symptoms in adolescence and risk of substance use disorders-A general population-based birth cohort study.Acta psychiatrica Scandinavica · 2023Article
- Employment trajectories until midlife in schizophrenia and other psychoses: the Northern Finland Birth Cohort 1966.Social psychiatry and psychiatric epidemiology · 2023Article
- Is early exposure to cannabis associated with bipolar disorder? Results from a Finnish birth cohort study.Addiction (Abingdon, England) · 2022Observational
- Diagnosed Incidence of Non-Affective Psychotic Disorders Amongst Adolescents in British Columbia and Sociodemographic Risk Factors: A Retrospective Cohort Study.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Article
- A population-based follow-up study shows high psychosis risk in women with PCOS.Archives of women's mental health · 2022Article
- Parental smoking and young adult offspring psychosis, depression and anxiety disorders and substance use disorder.European journal of public health · 2022Article
- Does cannabis use in adolescence predict self-harm or suicide? Results from a Finnish Birth Cohort Study.Acta psychiatrica Scandinavica · 2022Article
- Return to the labour market in schizophrenia and other psychoses: a register-based Northern Finland Birth Cohort 1966 study.Social psychiatry and psychiatric epidemiology · 2021Article
- Adolescent cannabis use, depression and anxiety disorders in the Northern Finland Birth Cohort 1986.BJPsych open · 2021Article
- Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.Social psychiatry and psychiatric epidemiology · 2020Article
- Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966.Schizophrenia research · 2019Article
- First Presentation With Psychotic Symptoms in a Population-Based Sample.Psychiatric services (Washington, D.C.) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsFew studies have compared time trends for the incidence of psychosis. To date, the results have been inconsistent, showing a decline, an increase or no significant change. As far as we know, no studies explored changes in prevalence of early risk factors. The aim of this study was to investigate differences in early risk factors and cumulative incidences of psychosis by type of psychosis in two comparable birth cohorts.
methodsThe Northern Finland Birth cohorts (NFBCs) 1966 (N = 12 058) and 1986 (N = 9432) are prospective general population-based cohorts with the children followed since mother's mid-pregnancy. The data for psychoses, i.e. schizophrenia (narrow, spectrum), bipolar disorder with psychotic features, major depressive episode with psychotic features, brief psychosis and other psychoses (ICD 8-10) were collected from nationwide registers including both inpatients and outpatients. The data on early risk factors including sex and place of birth of the offspring, parental age and psychosis, maternal education at birth were prospectively collected from the population registers. The follow-up reached until the age of 27 years.
resultsAn increase in the cumulative incidence of all psychoses was seen (1.01% in NFBC 1966 v. 1.90% in NFBC 1986; p < 0.001), which was due to an increase in diagnosed affective and other psychoses. Earlier onset of cases and relatively more psychoses in women were observed in the NFBC 1986. Changes in prevalence of potential early risk factors were identified, but only parental psychosis was a significant predictor in both cohorts (hazard ratios ≥3.0; 95% CI 1.86-4.88). The difference in psychosis incidence was not dependent on changes in prevalence of studied early risk factors.
conclusionsSurprisingly, increase in the cumulative incidence of psychosis and also changes in the types of psychoses were found between two birth cohorts 20 years apart. The observed differences could be due to real changes in incidence or they can be attributable to changes in diagnostic practices, or to early psychosis detection and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.