ArticleMolecular endocrinology (Baltimore, Md.)2016
Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.
Article in Molecular endocrinology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights.Iranian journal of medical sciences · 2025Review
- Leveraging epigenetic aberrations in the pathogenesis of endometriosis: from DNA methylation to non-coding RNAs.Frontiers in genetics · 2025Review
- Steroidogenic Factor-1 form and function: From phospholipids to physiology.Advances in biological regulation · 2024Review
- TNFα-Induced Altered miRNA Expression Links to NF-κB Signaling Pathway in Endometriosis.Inflammation · 2023Article
- The Pathological Role of miRNAs in Endometriosis.Biomedicines · 2023Review
- TNFα-induced altered miRNA expression links to NF-κB signaling pathway in endometriosis.Research square · 2023Article
- Steroidogenic Factor 1 Regulation of the Hypothalamic-Pituitary-Ovarian Axis of Adult Female Mice.Endocrinology · 2022Article
- Effectiveness of Gamma Oryzanol on prevention of surgical induced endometriosis development in rat model.Scientific reports · 2022Article
- Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature.International journal of women's health · 2021Review
- Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis.Journal of clinical medicine · 2020Review
- COUP-TFII in Health and Disease.Cells · 2019Review
- Increased circulating miR-370-3p regulates steroidogenic factor 1 in endometriosis.American journal of physiology. Endocrinology and metabolism · 2019Article
- The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Endometriosis andExperimental and therapeutic medicine · 2018Review
- Generation of Mouse for Conditional Expression of Forkhead Box A2.Endocrinology · 2018Article
- MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells.EXCLI journal · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Epigenetic silencing of steroidogenic factor 1 (SF1) is lost in endometriosis, potentially contributing to de novo local steroidogenesis favoring inflammation and growth of ectopic endometrial tissue. In this study, we examine the impact of SF1 expression in the eutopic uterus by a novel mouse model that conditionally expresses SF1 in endometrium. In vivo SF1 expression promoted the development of enlarged endometrial glands and attenuated estrogen and progesterone responsiveness. Endometriosis induction by autotransplantation of uterine tissue to the mesenteric membrane resulted in the increase in size of ectopic lesions from SF1-expressing mice. By integrating the SF1-dependent transcriptome with the whole genome binding profile of SF1, we identified uterine-specific SF1-regulated genes involved in Wingless and Progesterone receptor-Hedgehog-Chicken ovalbumin upstream promoter transcription factor II signaling for gland development and epithelium-stroma interaction, respectively. The present results indicate that SF1 directly contributes to the abnormal uterine gland morphogenesis, an inhibition of steroid hormone signaling and activation of an immune response, in addition to previously postulated estrogen production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.