ArticleMagnetic resonance in medicine2017
Metabolite diffusion up to very high b in the mouse brain in vivo: Revisiting the potential correlation between relaxation and diffusion properties.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Scattering approach to diffusion quantifies axonal damage in brain injury.Nature communications · 2025Article
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- High-resolution, volumetric diffusion-weighted MR spectroscopic imaging of the brain.Magnetic resonance in medicine · 2025Article
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- Universal dynamic fitting of magnetic resonance spectroscopy.Magnetic resonance in medicine · 2024Article
- Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Macromolecular background signal and non-Gaussian metabolite diffusion determined in human brain using ultra-high diffusion weighting.Magnetic resonance in medicine · 2022Article
- Assessing potential correlation between TMagnetic resonance in medicine · 2022Article
- Combined diffusion-relaxometry microstructure imaging: Current status and future prospects.Magnetic resonance in medicine · 2021Review
- Contribution of macromolecules to brainNMR in biomedicine · 2021Article
- Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in mouse brain.NMR in biomedicine · 2021Article
- Changes in the intracellular microenvironment in the aging human brain.Neurobiology of aging · 2020Article
- Challenges for biophysical modeling of microstructure.Journal of neuroscience methods · 2020Review
- Revisiting double diffusion encoding MRS in the mouse brain at 11.7T: Which microstructural features are we sensitive to?NeuroImage · 2020Article
- Glutamate diffusion in the rat brain in vivo under light and deep anesthesia conditions.Magnetic resonance in medicine · 2019Article
- Brain Metabolite Diffusion from Ultra-Short to Ultra-Long Time Scales: What Do We Learn, Where Should We Go?Frontiers in neuroscience · 2018Article
- Modeling diffusion of intracellular metabolites in the mouse brain up to very high diffusion-weighting: Diffusion in long fibers (almost) accounts for non-monoexponential attenuation.Magnetic resonance in medicine · 2017Article
- Probing metabolite diffusion at ultra-short time scales in the mouse brain using optimized oscillating gradients and "short"-echo-time diffusion-weighted MRS.NMR in biomedicine · 2017Article
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3 authors.
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Abstract
purposeTo assess the potential correlation between metabolites diffusion and relaxation in the mouse brain, which is of importance for interpreting and modeling metabolite diffusion based on pure geometry, irrespective of relaxation properties (multicompartmental relaxation or surface relaxivity).
methodsA new diffusion-weighted magnetic resonance spectroscopy sequence is introduced, dubbed "STE-LASER," which presents several nice properties, in particular the absence of cross-terms with selection gradients and a very clean localization. Metabolite diffusion is then measured in a large voxel in the mouse brain at 11.7 Tesla using a cryoprobe, resulting in excellent signal-to-noise ratio, up to very high b-values under different echo time, mixing time, and diffusion time combinations.
resultsOur results suggest that the correlation between relaxation and diffusion properties is extremely small or even nonexistent for metabolites in the mouse brain.
conclusionThe present work strongly supports the interpretation and modeling of metabolite diffusion primarily based on geometry, irrespective of relaxation properties, at least under current experimental conditions. Magn Reson Med 77:1390-1398, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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