Evidence map›Paper›PMID 27018370›Full record

ArticleMagnetic resonance in medicine2017

Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans.

Luning Wang, Mikko J Nissi, Ferenc Toth, Casey P Johnson, Michael Garwood, Cathy S Carlson, Jutta Ellermann

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  3. Review
  4. Article
  5. QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Article
  20. In vivo visualization using MRI TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Luning WangCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Mikko J NissiDepartment of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Ferenc TothDepartment of Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Casey P JohnsonCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Michael GarwoodCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Cathy S CarlsonDepartment of Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Jutta EllermannCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USResonance Research (United States) · USUniversity of Eastern Finland · FI

Funding

NMR Imaging and SpectroscopyP41EB015894 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2017
$8.4M
Comparative Medicine and Pathology TrainingT32OD010993 · OD · UNIVERSITY OF MINNESOTA · PI DAVID R BROWN, Cathy S. Carlson · 2012 to 2026
$6.2M
Development and MRI characterization of a goat model of human osteochondrosisK01OD021293 · OD · UNIVERSITY OF MINNESOTA · PI TOTH, FERENC · 2015 to 2019
$650k
In Vivo MRI Characterization of an Animal Model of OsteochondrosisR21AR065385 · NIAMS · UNIVERSITY OF MINNESOTA · PI CARLSON, CATHY S. · 2014 to 2015
$354k
NIAMS NIH HHS R21 AR065385NIBIB NIH HHS P41 EB015894NIH HHS K01 OD021293NIH HHS T32 OD010993
6 · The paper itself

Abstract

purposeTo use quantitative susceptibility mapping (QSM) to investigate changes in cartilage canals in the distal femur of juvenile goats after their surgical transection.

methodsChondronecrosis was surgically induced in the right medial femoral condyles of four 4-day-old goats. Both the operated and control knees were harvested at 2, 3, 5, and 10 weeks after the surgeries. Ex vivo MRI scans were conducted at 9.4 Tesla using T

resultsBoth the histological sections and the T

conclusionAbnormal cartilage canals were directly visualized in areas of surgically induced chondronecrosis. Quantitative susceptibility mapping enabled investigation of the vascular changes accompanying chondronecrosis in juvenile goats. Magn Reson Med 77:1276-1283, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AlgorithmsAsymptomatic DiseasesAnimalsCartilage, ArticularGoatsImage EnhancementImage Interpretation, Computer-AssistedIn Vitro TechniquesMagnetic Resonance ImagingOsteochondritis DissecansReproducibility of ResultsSensitivity and Specificitycartilage canalschondronecrosisepiphyseal cartilagehigh-field MRIOCDosteochondritis dissecansosteochondrosisQSMquantitative susceptibility mappingvascular canal abnormality

Identifiers

PMID27018370
PMCPMC5382980
OpenAlexW2307870967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.