Evidence map›Paper›PMID 27018193›Full record

ReviewF1000Research2016

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response.

Kenneth E Bernstein, Zakir Khan, Jorge F Giani, Tuantuan Zhao, Masahiro Eriguchi, Ellen A Bernstein, Romer A Gonzalez-Villalobos, Xiao Z Shen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in F1000Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Association of the rs4646994 inTranslational medicine communications · 2022
    Article
  3. Renin-Angiotensin System and Cardiovascular Functions.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kenneth E BernsteinDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Zakir KhanDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jorge F GianiDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Tuantuan ZhaoDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Masahiro EriguchiDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ellen A BernsteinDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Romer A Gonzalez-VillalobosDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Xiao Z ShenDepartment of Biomedical Sciences and the Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · US

Funding

RAS and InjuryR01HL110353 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2011 to 2015
$2.2M
Renal ACE, salt sensitivity and blood pressure controlR03DK101592 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI GONZALEZ-VILLALOBOS, ROMER ANDRES · 2014 to 2016
$638k
Carboxypeptidase ACE and MHC Class I PresentationR21AI114965 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2015 to 2016
$481k
NHLBI NIH HHS R01 HL110353NIAID NIH HHS R21 AI114965NIDDK NIH HHS R03 DK101592
6 · The paper itself

Abstract

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

Indexed as

ACEangiotensinAngiotensin-converting enzymeimmune responserenin-angiotensin system

Identifiers

PMID27018193
PMCPMC4806706
OpenAlexW2324814274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.