ArticleInternational journal of epidemiology2017
Cohort Profile: The Saguenay Youth Study (SYS).
Article in International journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Pooled it
- The Effect of Age of Initiation of Cannabis Use on Psychosis, Depression, and Anxiety among Youth under 25 Years.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Pooled it
- Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis.International journal of obesity (2005) · 2018Pooled it
- Cellular correlates of cortical thinning throughout the lifespan.Scientific reports · 2020Trial
- The tangential growth of the human visual cortex and maternal smoking during pregnancy.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Dense longitudinal neuroimaging reveals individual brain change trajectories.Trends in cognitive sciences · 2026Review
- Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex.Research square · 2025Article
- Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex.bioRxiv : the preprint server for biology · 2025Article
- Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes.Cell genomics · 2024Article
- Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Development and Maturation of the Human Brain, from Infancy to Adolescence.Current topics in behavioral neurosciences · 2024Review
- Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability.Frontiers in psychiatry · 2024Article
- Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability.medRxiv : the preprint server for health sciences · 2023Article
- The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.Scientific reports · 2023Article
- Roadmap for an imaging and modelling paediatric study in rural NZ.Frontiers in physiology · 2023Article
- Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction.Communications medicine · 2022Article
- The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students.Brain structure & function · 2021Article
- A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents.Molecular psychiatry · 2021Article
- Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability.Molecular psychiatry · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The Saguenay Youth Study (SYS) is a two-generational study of adolescents and their parents (n = 1029 adolescents and 962 parents) aimed at investigating the aetiology, early stages and trans-generational trajectories of common cardiometabolic and brain diseases. The ultimate goal of this study is to identify effective means for increasing healthy life expectancy. The cohort was recruited from the genetic founder population of the Saguenay Lac St Jean region of Quebec, Canada. The participants underwent extensive (15-h) phenotyping, including an hour-long recording of beat-by-beat blood pressure, magnetic resonance imaging of the brain and abdomen, and serum lipidomic profiling with LC-ESI-MS. All participants have been genome-wide genotyped (with ∼ 8 M imputed single nucleotide polymorphisms) and a subset of them (144 adolescents and their 288 parents) has been genome-wide epityped (whole blood DNA, Infinium HumanMethylation450K BeadChip). These assessments are complemented by a detailed evaluation of each participant in a number of domains, including cognition, mental health and substance use, diet, physical activity and sleep, and family environment. The data collection took place during 2003-12 in adolescents (full) and their parents (partial), and during 2012-15 in parents (full). All data are available upon request.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.