ArticleGenetics2016
Natural Selection and Genetic Diversity in the Butterfly Heliconius melpomene.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 107 citations in OpenAlex.
- Summer Rainfall Drives Adaptation with Gene Flow in a Widespread Butterfly.Molecular ecology · 2026Article
- Influence of geography, seasonality and experimental selection on Chironomus riparius recombination rates.BMC genomics · 2026Article
- Lepidopteran Genomes Have Denser Transposable Elements in Smaller Chromosomes, Likely Driven by Non-allelic Homologous Recombination.Genome biology and evolution · 2025Article
- Species Delimitation Using Genomic Data: Options and Limitations.Molecular ecology · 2025Article
- Whole genomes from the extinct Xerces Blue butterfly can help identify declining insect species.eLife · 2024Article
- Population genomic evidence of a putative 'far-west' African cryptic taxon in the Anopheles gambiae complex.Communications biology · 2024Article
- Improved assembly of the Pungitius pungitius reference genome.G3 (Bethesda, Md.) · 2024Article
- The role of recombination dynamics in shaping signatures of direct and indirect selection across theProceedings. Biological sciences · 2024Article
- Determinants of genetic diversity in Neotropical salamanders (Plethodontidae: Bolitoglossini).Ecology and evolution · 2023Article
- Demographically explicit scans for barriers to gene flow using gIMble.PLoS genetics · 2023Article
- Nascent evolution of recombination rate differences as a consequence of chromosomal rearrangements.PLoS genetics · 2023Article
- Base Composition, Codon Usage, and Patterns of Gene Sequence Evolution in Butterflies.Genome biology and evolution · 2023Article
- Evidence for Two Soybean Looper Strains in the United States with Limited Capacity for Cross-Hybridization.Genes · 2023Article
- The fitness of an introgressing haplotype changes over the course of divergence and depends on its size and genomic location.PLoS biology · 2023Article
- Testing hypotheses of a coevolutionary key innovation reveals a complex suite of traits involved in defusing the mustard oil bomb.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- The genome sequence of the scarce swallowtail, Iphiclides podalirius.G3 (Bethesda, Md.) · 2022Article
- Repeated genetic adaptation to altitude in two tropical butterflies.Nature communications · 2022Article
- Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.Nature communications · 2022Article
- Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci.Molecular biology and evolution · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
A combination of selective and neutral evolutionary forces shape patterns of genetic diversity in nature. Among the insects, most previous analyses of the roles of drift and selection in shaping variation across the genome have focused on the genus Drosophila A more complete understanding of these forces will come from analyzing other taxa that differ in population demography and other aspects of biology. We have analyzed diversity and signatures of selection in the neotropical Heliconius butterflies using resequenced genomes from 58 wild-caught individuals of Heliconius melpomene and another 21 resequenced genomes representing 11 related species. By comparing intraspecific diversity and interspecific divergence, we estimate that 31% of amino acid substitutions between Heliconius species are adaptive. Diversity at putatively neutral sites is negatively correlated with the local density of coding sites as well as nonsynonymous substitutions and positively correlated with recombination rate, indicating widespread linked selection. This process also manifests in significantly reduced diversity on longer chromosomes, consistent with lower recombination rates. Although hitchhiking around beneficial nonsynonymous mutations has significantly shaped genetic variation in H. melpomene, evidence for strong selective sweeps is limited overall. We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation. On the whole, our study suggests that positive selection is less pervasive in these butterflies as compared to fruit flies, a fact that curiously results in very similar levels of neutral diversity in these very different insects.
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