Evidence map›Paper›PMID 27017495›Full record

ArticleEuropean journal of applied physiology2016

Acute effects of exercise under different levels of blood-flow restriction on muscle activation and fatigue.

Pedro Fatela, Joana F Reis, Goncalo V Mendonca, Janne Avela, Pedro Mil-Homens

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In one paragraph

Article in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06762912 (The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults - a Randomized Crossover Trial), which is not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06762912 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Short-term Effect of Low-load Resistance Training with Blood-flow Restriction on Somatosensory-evoked Potentials in Healthy Young Adults - a Randomized Crossover Trial

TypeinterventionalSponsorUniversity of SharjahRan2025 to 2025Enrolled30ConditionsThe Current Study Focuses on Investigating the Short-term Effect of BFRT on the Somatosensory System Among Healthy Young AdultsArmsPassive application of BFR cuff, Resistance exercise with BFR, Resistance exercise without BFR
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pedro FatelaFaculdade de Motricidade Humana, CIPER, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, 1499-002, Lisboa, Portugal. pedrofatela@gmail.com.
Joana F ReisFaculdade de Motricidade Humana, CIPER, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, 1499-002, Lisboa, Portugal.
Goncalo V MendoncaFaculdade de Motricidade Humana, CIPER, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, 1499-002, Lisboa, Portugal.
Janne AvelaDepartment of Biology and Physical Activity, Neuromuscular Research Center, University of Jyvaskyla, Jyvaskyla, Finland.
Pedro Mil-HomensFaculdade de Motricidade Humana, CIPER, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, 1499-002, Lisboa, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is some evidence that muscular activation during exercise is enhanced by higher levels of blood flow restriction (BFR). However, the impact of different relative levels of BFR on the acute neuromuscular response to resistance exercise is not yet fully understood. We examined the acute effects of low-intensity knee extensions [20 % of 1-repetition maximum (1RM)] with BFR on muscle activation, neuromuscular fatigue and torque in the rectus femoris (RF) and vastus medialis (VM) muscles.

methodsFourteen men (24.8 ± 5.4 years) exercised at 20 % 1RM combined with 40, 60 and 80 % BFR. Restrictive pressures were calculated based on direct blood-flow measurements taken at rest on each participant. Torque was determined during pre- and post-exercise maximal voluntary contractions. Surface electromyographic activity [root mean square (RMS)] was obtained during dynamic and sustained isometric contractions before and after exercise. The median frequency (MF) of the electromyographic power spectrum was computed for isometric contractions.

resultsTorque only decreased in the 80 % BFR condition (-5.2 %; p < 0.01). Except for the VM in the 40 % BFR, MF decreased in both muscles post-exercise in all conditions (p < 0.01). MF decrements were of greater magnitude post-exercise at higher levels of BFR. RMS increased within all sets in both muscles (p < 0.01) and attained higher values in the 80 % BFR condition; except for set 1 in the RF muscle (p < 0.01).

conclusionMuscular activation, as well as neuromuscular fatigue, varies as a function of relative BFR intensity. Therefore, the individual determination of vascular restriction levels is crucial before engaging in BFR exercise.

Indexed as

AdultElectromyographyExerciseHumansIsometric ContractionKneeKnee JointMaleMuscle FatigueMuscle, SkeletalQuadriceps MuscleRegional Blood FlowResistance TrainingRestTorqueYoung AdultElectromyographyMuscular activationNeuromuscular fatigueResistance trainingVascular occlusion

Identifiers

PMID27017495

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.