Evidence map›Paper›PMID 27017391›Full record

ArticleThe Korean journal of internal medicine2016

Periodontitis is associated with rheumatoid arthritis: a study with longstanding rheumatoid arthritis patients in Korea.

In Ah Choi, Jin-Hee Kim, Yong Mi Kim, Joo Youn Lee, Kyung Hwa Kim, Eun Young Lee, Eun Bong Lee, Yong-Moo Lee, Yeong Wook Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

In Ah ChoiDepartment of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Jin-Hee KimDepartment of Periodontology, Seoul National University School of Dentistry, Seoul, Korea.
Yong Mi KimDepartment of Periodontology, Seoul National University School of Dentistry, Seoul, Korea.
Joo Youn LeeDepartment of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea.
Kyung Hwa KimDepartment of Periodontology, Seoul National University School of Dentistry, Seoul, Korea.
Eun Young LeeDepartment of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Eun Bong LeeDepartment of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Yong-Moo LeeDepartment of Periodontology, Seoul National University School of Dentistry, Seoul, Korea.
Yeong Wook SongDepartment of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Seoul National University · KRSeoul National University Dental Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsA cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation of rheumatoid arthritis (RA).

methodsTwo hundred sixty-four RA patients and 88 age- and sex-matched controls underwent dental exam. Additionally, clinical manifestations including disease activity and anti-citrullinated protein antibodies were evaluated in RA patients.

resultsThe prevalence of moderate or severe periodontitis was higher in RA patients compared to controls (63.6% vs 34.1%, p < 0.001). In markers of periodontal inflammation, bleeding on probing was correlated with disease activity score 28 (r = 0.128, p = 0.041), RA disease duration (r = 0.211, p = 0.001), erythrocyte sedimentation rate (ESR; r = 0.141, p = 0.023), anti-cyclic citrullinated peptide antibody (r = 0.183, p = 0.009), and anti-citrullinated α-enolase peptide-1 antibody (r = 0.143, p = 0.025). Gingival index was correlated with RA duration (r = 0.262, p < 0.001), ESR (r = 0.162, p = 0.009), anti-cyclic citrullinated peptide antibody (r = 0.203, p = 0.004) and anti-citrullinated α-enolase peptide-1 antibody (r = 0.225, p < 0.001). Periodontal structural damage represented by probing pocket depth and clinical attachment level were less in RA patients with human leukocyte antigen (HLA)-DRB1 shared epitope compared than those without shared epitope (p = 0.005 and p =0.006, respectively).

conclusionsThe prevalence of moderate or severe periodontitis was increased in RA patients compared to controls. Periodontal inflammation was correlated with RA disease duration, ESR, and anti-citrullinated protein antibodies. Periodontal structural damage was less in RA patients with HLA-DRB1 shared epitope.

Indexed as

AgedArthritis, RheumatoidAutoantibodiesCase-Control StudiesCross-Sectional StudiesFemaleHLA-DRB1 ChainsHumansMaleMiddle AgedPeptides, CyclicPeriodontitisPrevalenceProspective StudiesRepublic of KoreaAutoantibodiescyclic citrullinated peptideHLA-DRB1 ChainsPeptides, CyclicArthritis, rheumatoidPeriodontitis

Identifiers

PMID27017391
PMCPMC5016284
OpenAlexW2304580536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.