Evidence map›Paper›PMID 27017342›Full record

SynthesisJournal of neurology2016

TGFBR2 mutation and MTHFR-C677T polymorphism in a Mexican mestizo population with cervico-cerebral artery dissection.

Angélica Ruiz-Franco, Miguel A Barboza, Aurelio Jara-Prado, Samuel Canizales-Quinteros, Paola Leon-Mimila, Nayelli Arguelles-Morales, Juan-Camilo Vargas-González, Alejandro Quiroz-Compean, Antonio Arauz

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Arterial dissections: Common features and new perspectives.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Angélica Ruiz-FrancoStroke Clinic, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Insurgentes Sur 3877 Col. La Fama, C.P. 14269, Mexico, Mexico.
Miguel A BarbozaStroke Clinic, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Insurgentes Sur 3877 Col. La Fama, C.P. 14269, Mexico, Mexico. miguel.barboza_e@ucr.ac.cr.
Aurelio Jara-PradoGenetics Department, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Mexico, Mexico.
Samuel Canizales-QuinterosUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de Mexico (UNAM)-Instituto Nacional de Medicina Genómica (INMEGEN), Mexico, Mexico.
Paola Leon-MimilaUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de Mexico (UNAM)-Instituto Nacional de Medicina Genómica (INMEGEN), Mexico, Mexico.
Nayelli Arguelles-MoralesStroke Clinic, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Insurgentes Sur 3877 Col. La Fama, C.P. 14269, Mexico, Mexico.
Juan-Camilo Vargas-GonzálezStroke Clinic, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Insurgentes Sur 3877 Col. La Fama, C.P. 14269, Mexico, Mexico.
Alejandro Quiroz-CompeanStroke Clinic, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Insurgentes Sur 3877 Col. La Fama, C.P. 14269, Mexico, Mexico.
Antonio ArauzStroke Clinic, National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez, Insurgentes Sur 3877 Col. La Fama, C.P. 14269, Mexico, Mexico.
Instituto Nacional de Neurología y Neurocirugía · MXUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous cervico-cerebral artery dissection (CCAD) is a common condition found among young patients with ischemic stroke. We examined the possible association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR)-C677T and the gene mutation in transforming growth factor beta receptor II (TGFBR2) in a cohort of CCAD patients. One-hundred CCAD cases (65 males; mean age: 38.08 ± 10.68 years) and 100 matching controls were included. Ancestry informative markers (AIMs) were used to increase internal validity of the genetic analysis. Genotypes of the C677T polymorphism in the MTHFR gene were determined by polymerase chain reaction and restriction fragment length polymorphism; direct sequencing was used for a mutation analysis of the TGFBR2 gene. Associations were evaluated using a multivariate statistics, and Hardy-Weinberg equilibrium was analyzed. We also incorporated our data into a meta-analysis of the MTHFR-C677T. Sixty-three patients presented with vertebral and 37 with carotid artery dissection. Ancestry markers found a call rate on each over 95 %. All AIMs did not deviate from Hardy-Weinberg equilibrium (p > 0.05). The homozygous TT genotype was more frequent in cases (OR 2.04, CI 95 % 1.53-2.72, p = 0.005), whereas no significant difference was found on heterozygous CT genotype. TGFBR2 mutation was not present in our samples. In the meta-analysis of MTHFR/C677T variant, a total 613 cases and 1547 controls were analyzed; we found a moderate association for the recessive model genotype (OR 2.04, CI 95 % 1.53-2.72; p = 0.342; Z = 4.83; I (2) = 11.3). This study supports a positive association between the MTHFR-C677T polymorphism and genetically confirmed Mexican mestizo CCAD patients.

Indexed as

AdultAortic DissectionCerebral Arterial DiseasesCohort StudiesFemaleGenetic Predisposition to DiseaseHumansIndians, North AmericanIntracranial AneurysmMaleMethylenetetrahydrofolate Reductase (NADPH2)MexicoMutationPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanProtein Serine-Threonine KinasesReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IIAncestry studiesC677T-MTHFR polymorphismCervico-cerebral artery dissectionHyperhomocysteinemiaIschemic strokeMethylenetetrahydrofolate reductaseTGFBR2 gene mutation

Identifiers

PMID27017342
OpenAlexW2303045449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.