Evidence map›Paper›PMID 27017326›Full record

ReviewEpilepsy & behavior : E&B2016

Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy.

Camille Garcia-Ramos, Jack J Lin, Tanja S Kellermann, Leonardo Bonilha, Vivek Prabhakaran, Bruce P Hermann

Abstract readReview
In one paragraph

Review in Epilepsy & behavior : E&B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Network topology of the cognitive phenotypes of temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2021
    Article
  9. The Cognitive Connectome in Healthy Aging.Frontiers in aging neuroscience · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camille Garcia-RamosDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: garciaramos@wisc.edu.
Jack J LinDepartment of Neurology, University of California-Irvine, Irvine, CA 92697, USA.
Tanja S KellermannDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
Leonardo BonilhaDepartment of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.
Vivek PrabhakaranDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Radiology, University of Wisconsin-Madison, Madison, WI 53792, USA.
Bruce P HermannDepartment of Neurology, University of Wisconsin-Madison, Madison, WI 53705, USA.

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Neuropsychological Progression of New Onset EpilepsyR01NS044351 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI HERMANN, BRUCE PHILLIP · 2003 to 2015
$6.3M
NCATS NIH HHS UL1 TR000062NCI NIH HHS T32 CA009206NINDS NIH HHS R01 NS044351
6 · The paper itself

Abstract

The recent revision of the classification of the epilepsies released by the ILAE Commission on Classification and Terminology (2005-2009) has been a major development in the field. Papers in this section of the special issue explore the relevance of other techniques to examine, categorize, and classify cognitive and behavioral comorbidities in epilepsy. In this review, we investigate the applicability of graph theory to understand the impact of epilepsy on cognition compared with controls and, then, the patterns of cognitive development in normally developing children which would set the stage for prospective comparisons of children with epilepsy and controls. The overall goal is to examine the potential utility of this analytic tool and approach to conceptualize the cognitive comorbidities in epilepsy. Given that the major cognitive domains representing cognitive function are interdependent, the associations between neuropsychological abilities underlying these domains can be referred to as a cognitive network. Therefore, the architecture of this cognitive network can be quantified and assessed using graph theory methods, rendering a novel approach to the characterization of cognitive status. We first provide fundamental information about graph theory procedures, followed by application of these techniques to cross-sectional analysis of neuropsychological data in children with epilepsy compared with that of controls, concluding with prospective analysis of neuropsychological development in younger and older healthy controls. This article is part of a Special Issue entitled "The new approach to classification: Rethinking cognition and behavior in epilepsy".

Indexed as

Models, TheoreticalNeuropsychological TestsCognitionCognition DisordersComorbidityCross-Sectional StudiesEpilepsyHumansProspective StudiesCognitionGraph theoryNeuropsychological assessmentPediatric epilepsy

Identifiers

PMID27017326
PMCPMC5035172

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.