ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016
Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Convergent validity of EQ-5D with core outcomes in dementia: a systematic review.Health and quality of life outcomes · 2022Pooled it
- Pooled it
- Can Persons with Dementia Meaningfully Participate in Advance Care Planning Discussions? A Mixed-Methods Study of SPIRIT.Journal of palliative medicine · 2019Trial
- SPIRIT advance care planning intervention in early stage dementias: An NIH stage I behavioral intervention development trial.Contemporary clinical trials · 2018Trial
- Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Co-designing an Outpatient Clinical Decision Support Prototype for Managing Social Risks in Patients Living with Dementia.Applied clinical informatics · 2026Article
- Super-Resolved Spatial Transcriptomics Reveals Early Changes in RNA Localization in the 5xFAD Hippocampus.bioRxiv : the preprint server for biology · 2025Article
- The Cost-Effectiveness of an Intervention to Preserve Independence in People With Dementia (Vs. No Intervention): A Decision-Analytic (Markov) Model Analysis.International journal of geriatric psychiatry · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Informal care for people with dementia in Europe.The journal of prevention of Alzheimer's disease · 2025Article
- A GBD 2021 study of Alzheimer's disease and other dementias attributable to metabolic risk factors and forecasts to 2045 in China.Frontiers in public health · 2025Article
- Article
- Disease severity and mortality in Alzheimer's disease: an analysis using the U.S. National Alzheimer's Coordinating Center Uniform Data Set.BMC neurology · 2023Observational
- Alzheimer's Disease: Epidemiology and Clinical Progression.Neurology and therapy · 2022Review
- A comparison of two approaches for modeling dementia progression in a changing patient context.International journal of geriatric psychiatry · 2022Article
- Using dynamic microsimulation to project cognitive function in the elderly population.PloS one · 2022Article
- Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Classification, Prediction, and Concordance of Cognitive and Functional Progression in Patients with Mild Cognitive Impairment in the United States: A Latent Class Analysis.Journal of Alzheimer's disease : JAD · 2021Article
- A prediction model for one- and three-year mortality in dementia: results from a nationwide hospital-based cohort of 50,993 patients in the Netherlands.Age and ageing · 2020Article
- Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
introductionWe develop a multidomain model to predict progression of Alzheimer's disease dementia (AD).
methodsData from the US National Alzheimer's Coordinating Center (n = 3009) are used to examine change in symptom status and to estimate transition probabilities between health states described using cognitive function, functional ability, and behavior. A model is used to predict progression and to assess a hypothetical treatment scenario that slows mild to moderate AD progression.
resultsMore than 70% of participants moved state over 12 months. The majority moved in domains other than cognitive function. Over 5 years, of those alive more than half are in severe AD health states. Assessing an intervention scenario, we see fewer years in more severe health states and a potential impact (life years saved) due to mortality improvements. DISCUSSION: The model developed is exploratory and has limitations but illustrates the importance of using a multidomain approach when assessing impacts of AD and interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.