Observational studyJournal of the American Heart Association2016
Dyslipidemia and the Risk of Developing Hypertension in a Working-Age Male Population.
Observational study in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 226 citations in OpenAlex.
- Re-thinking the link between exposure to mercury and blood pressure.Archives of toxicology · 2025Pooled it
- An RCT META analysis based on the efficacy of Tai Chi exercise therapy on blood pressure and blood lipids in patients with essential hypertension.Frontiers in cardiovascular medicine · 2025Pooled it
- Ring-Augmented Versus Non-Ring Augmented Sleeve Gastrectomy in Patients with BMI > 50 kg/m²: 3-Year Follow-up of a Randomized Controlled Trial.Obesity surgery · 2026Trial
- Dyslipidemia Impacts Cardiometabolic Health and CVD Risk in a Relatively Young Otherwise Healthy Population.Journal of clinical hypertension (Greenwich, Conn.) · 2025Trial
- Association of lncRNA PVT1 Gene Polymorphisms with the Risk of Essential Hypertension in Chinese Population.BioMed research international · 2022Trial
- Pharmacokinetic and Safety Profiles of a Fixed-Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3-Period Replicate Crossover Study.Clinical pharmacology in drug development · 2020Trial
- Multi-horizon machine learning for population-level hypertension risk stratification in the UK Biobank.European heart journal. Digital health · 2026Article
- Discordance between remnant cholesterol and low-density lipoprotein cholesterol predicts incident hypertension: a 9-year prospective cohort study in Chinese adults.BMC cardiovascular disorders · 2026Article
- Prevalence and risk factor analysis of early-onset dyslipidemia-a cross-sectional study of 3.7 million population.Lipids in health and disease · 2026Article
- Socio-demographic and clinical determinants of dyslipidaemia in hypertensive patients at the Effia Nkwanta Hospital; a cross-sectional study.Scientific reports · 2026Article
- Clustering metabolic and behavioral risk factors for hypertension: evidence from a longitudinal cohort in western Iran.Scientific reports · 2026Article
- Association between blood lipid levels, BMI, and hypertension among employees in petrochemical enterprises.Frontiers in cardiovascular medicine · 2026Article
- Association of radiation exposure and blood lipid derived indices with hypertension risk in radiation workers.Frontiers in public health · 2026Article
- Elevated level of estimated small dense LDL cholesterol is independently associated with the development of hypertension, regardless of LDL cholesterol level.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Independent and joint associations of hypertension and depression with cardiovascular diseases and all-cause mortality: a population-based cohort study.Journal of human hypertension · 2025Article
- Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals.Microbiology spectrum · 2025Article
- Novel predictive factors scoring model for persistent hypertension after adrenalectomy in patients with primary aldosteronism.Scientific reports · 2025Article
- Prevalence and Risk Factors of Hypertension Among Adults in Ernakulam District, Kerala: A Cross-Sectional Study.Cureus · 2025Article
- Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality among hypertension patients.Scientific reports · 2025Article
- Second Derivative of the Finger Photoplethysmogram Predicts the Risk of Developing Hypertension in Middle-Aged Men.Journal of atherosclerosis and thrombosis · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is one of the main comorbidities associated with dyslipidemia. This study aimed to examine the extent to which dyslipidemia increases the risk of developing hypertension in a Japanese working-age male population. METHODS AND
resultsWe analyzed data from 14 215 nonhypertensive male workers (age 38±9 years) who underwent annual medical checkups. Subjects were followed up for a median of 4 years to determine new-onset hypertension, defined as blood pressure (BP) ≥140/90 mm Hg or use of antihypertensive medication. The associations between serum lipid levels and development of hypertension were examined. During the follow-up period, 1483 subjects developed hypertension. After adjusting for age, body mass index, impaired fasting glucose/diabetes, baseline BP category, alcohol intake, smoking, exercise, and parental history of hypertension, subjects with a total cholesterol (TC) level ≥222 mg/dL were at a significantly increased risk of developing hypertension (hazard ratio: 1.28; 95% CI: 1.06-1.56) compared to subjects with a TC level ≤167 mg/dL. Similar results were observed for subjects with high low-density lipoprotein cholesterol (LDLC) and non-high-density lipoprotein cholesterol (HDLC) levels. A U-shaped relationship was found between HDLC level and risk of hypertension; compared to the third quintile, the multiadjusted hazard ratio was 1.22 (95% CI: 1.03-1.43) in the lowest quintile and 1.34 (95% CI: 1.12-1.60) in the highest quintile.
conclusionsElevated serum levels of TC, LDLC, and non-HDLC were associated with an increased risk of hypertension in working-age Japanese men. For HDLC, risk of hypertension was increased at both low and high levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.