ArticleJournal of the American Heart Association2016
Racial Differences in Electrocardiographic Characteristics and Prognostic Significance in Whites Versus Asians.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Artificial intelligence enabled ECG screening for left ventricular systolic dysfunction: a systematic review.Heart failure reviews · 2023Pooled it
- Obesity and shorter QT intervals: sex- and adiposity distribution-specific patterns of ventricular repolarization in healthy Asian youth.BMC cardiovascular disorders · 2026Observational
- Prevalence and Clinical Significance of Short PR Interval in 1310 Children and Adolescent Athletes: A Cross-Sectional Study.Sports medicine - open · 2026Article
- Enhanced Demographically Adaptive QT Correction Improves Pediatric Screening for Congenital Long QT Syndrome.medRxiv : the preprint server for health sciences · 2026Article
- From Empirical to More Precise Correction: Multidimensional Performance Evaluation of QTc Formulas in a Cohort of Healthy Asian Youth.Journal of the American Heart Association · 2026Article
- Artificial intelligence-enhanced electrocardiography to predict regurgitant valvular heart diseases: an international study.European heart journal · 2025Article
- The electrocardiogram reimagined: AI-ECG as a prognostic beacon for valvular heart disease.European heart journal · 2025Article
- Electrocardiogram characteristics and possible associated factors in healthy Japanese children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.BMC pediatrics · 2025Article
- Large-Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital-Based Controls and Moxifloxacin-Treated Cases.Clinical and translational science · 2025Article
- Reappraisal of the clinical and anatomic characteristics of idiopathic outflow tract ventricular arrhythmias with an R wave pattern break in precordial lead: A multi-center study.International journal of cardiology. Heart & vasculature · 2025Article
- Using artificial intelligence to spot heart failure from ECGs: is it prime time?European heart journal · 2025Article
- Comparison of machine learning and conventional criteria in detecting left ventricular hypertrophy and prognosis with electrocardiography.European heart journal. Digital health · 2025Article
- A Review of Racial Differences and Disparities in ECG.International journal of environmental research and public health · 2025Review
- Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross-Sectional Phase of Tehran Cohort Study.Health science reports · 2025Article
- Age-dependent implications of left ventricular hypertrophy regression in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Race, Sex, and Age Disparities in the Performance of ECG Deep Learning Models Predicting Heart Failure.Circulation. Heart failure · 2024Article
- Polypharmacy, Gender Disparities, and Ethnic and Racial Predispositions in Long QT Syndrome: An In-Depth Review.Cureus · 2023Review
- Are Electrocardiographic Criteria Reliable for Left Ventricular Hypertrophy Detection in Indian Adults?Cureus · 2023Article
- Electrocardiographic and biochemical analysis of anthracycline induced cardiotoxicity in breast cancer patients from Southern Sri Lanka.BMC cancer · 2023Article
- A Retrospective Clinical Evaluation of an Artificial Intelligence Screening Method for Early Detection of STEMI in the Emergency Department.Journal of Korean medical science · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundRacial differences in electrocardiographic (ECG) characteristics and prognostic significance among Whites and Asians are not well described. METHODS AND
resultsWe studied 2677 White Framingham Heart Study participants (57% women) and 2972 Asian (64% women) Singapore Longitudinal Aging Study participants (mean age 66 years in both) free of myocardial infarction or heart failure. Racial differences in ECG characteristics and effect on mortality were assessed. In linear regression models, PR interval was longer in Asians compared with Whites (multivariable-adjusted β±SE 5.0±1.4 ms in men and 6.6±0.9 ms in women, both P<0.0006). QT interval was shorter in Asian men (β±SE -6.2±1.2 ms, P<0.0001) and longer in Asian women (β±SE 3.6±0.9 ms, P=0.02) compared to White men and women, respectively. Asians had greater odds of having ECG left ventricular hypertrophy (LVH) compared with Whites (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.36-9.35 for men, OR 1.93, 95% CI 1.35-2.76 for women, both P<0.02). Over a mean follow-up of 11±3 years in Framingham and 8±3 years in Singapore, mortality rates were 24.5 and 13.4 per 1000 person-years among Whites and Asians, respectively. In Cox models, the presence of LVH had a greater effect on all-cause mortality in Asians compared with Whites (hazard ratio [HR] 2.66, 95% CI 1.83-3.88 vs HR 1.30, 95% CI 0.90-1.89, P for interaction=0.02).
conclusionOur findings from two large community-based cohorts show prominent race differences in ECG characteristics between Whites and Asians, and also suggest a differential association with mortality. These differences may carry implications for race-specific ECG reference ranges and cardiovascular risk.
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Registered trials
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