ArticleFertility and sterility2016
Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: The LIFE Study.
Article in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Relationship between maternal caffeine and coffee intake and pregnancy loss: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies.Frontiers in nutrition · 2022Pooled it
- Alcohol Use in Pregnancy and Miscarriage: A Systematic Review and Meta-Analysis.Alcoholism, clinical and experimental research · 2019Pooled it
- Predicting the likelihood of successful medical treatment of early pregnancy loss: development and internal validation of a clinical prediction model.Human reproduction (Oxford, England) · 2022Trial
- Trial
- Observational
- A prospective study of periconceptional perceived stress and rate of miscarriage.Human reproduction (Oxford, England) · 2026Article
- Leveraging health records to identify diagnoses associated with recurrent pregnancy loss across two medical centers.iScience · 2026Article
- Mobile device data for the study of miscarriage and its causes.npj women's health · 2026Article
- Preconception alcohol consumption in both partners and risk of miscarriage.Reproductive biomedicine online · 2025Article
- Transcriptomic alterations in the ovine caruncular endometrium due to imbalanced nutrition and FSH-induced ovarian hyperstimulation.BMC genomics · 2024Article
- Association between early spontaneous abortion and homocysteine metabolism.Frontiers in medicine · 2024Article
- Time-Varying Exposures and Miscarriage: A Comparison of Statistical Models Through Simulation.American journal of epidemiology · 2023Article
- Preconception Dietary Patterns and Associations With IVF Outcomes: An Ongoing Prospective Cohort Study.Frontiers in nutrition · 2022Article
- Diagnostic criteria for retained products of conception-A scoping review.Acta obstetricia et gynecologica Scandinavica · 2021Article
- Risk score to stratify miscarriage risk levels in preconception women.Scientific reports · 2021Article
- Association between Low House Cleaning Frequency, Cough and Risk of Miscarriage: A Case Control Study in China.International journal of environmental research and public health · 2021Article
- Prevalence and clinical, social, and health care predictors of miscarriage.BMC pregnancy and childbirth · 2021Article
- Male Preconception Marijuana Use and Spontaneous Abortion: A Prospective Cohort Study.Epidemiology (Cambridge, Mass.) · 2021Article
- Mifepristone followed by misoprostol compared with placebo followed by misoprostol as medical treatment for early pregnancy loss (the Triple M trial): A double-blind placebo-controlled randomised trial.EClinicalMedicine · 2021Article
- Evaluation of Chromosomal Structural Anomalies in Fertility Disorders.Medicina (Kaunas, Lithuania) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo estimate pregnancy loss incidence in a contemporary cohort of couples whose lifestyles were measured during sensitive windows of reproduction to identify factors associated with pregnancy loss for the continual refinement of preconception guidance.
designProspective cohort with preconception enrollment.
settingSixteen counties in Michigan and Texas. PATIENT(S): Three hundred forty-four couples with a singleton pregnancy followed daily through 7 postconception weeks of gestation. INTERVENTION(S): None. Couples daily recorded use of cigarettes, caffeinated and alcoholic beverages, and multivitamins. Women used fertility monitors for ovulation detection and digital pregnancy tests. Pregnancy loss was denoted by conversion to a negative pregnancy test, onset of menses, or clinical confirmation depending upon gestation. Using proportional hazards regression and accounting for right censoring, we estimated adjusted hazard ratios and 95% confidence intervals (aHR, 95% CI) for couples' lifestyles (cigarette smoking, alcoholic and caffeinated drinks, multivitamins) during three sensitive windows: preconception, early pregnancy, and periconception. MAIN OUTCOME MEASURE(S): Incidence and risk factors for pregnancy loss. RESULT(S): Ninety-eight of 344 (28%) women with a singleton pregnancy experienced an observed pregnancy loss. In the preconception window, loss was associated with female age ≥35 years (1.96, 1.13-3.38) accounting for couples' ages, women's and men's consumption of >2 daily caffeinated beverages (1.74, 1.07-2.81; and 1.73, 1.10-2.72, respectively), and women's vitamin adherence (0.45, 0.25-0.80). The findings were similar for lifestyle during the early pregnancy and periconception windows. CONCLUSION(S): Couples' preconception lifestyle factors were associated with pregnancy loss, although women's multivitamin adherence dramatically reduced risk. The findings support continual refinement and implementation of preconception guidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.