Observational studyAnnals of surgical oncology2016
Postoperative Systemic Inflammatory Response, Complication Severity, and Survival Following Surgery for Colorectal Cancer.
Observational study in Annals of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systemic inflammatory response after robotic versus laparoscopic abdominal surgery: a systematic review and meta-analysis with colorectal cancer subgroup analysis.Journal of robotic surgery · 2026Pooled it
- Impact of the preoperative prognostic nutritional index on postoperative and survival outcomes in colorectal cancer patients who underwent primary tumor resection: a systematic review and meta-analysis.International journal of colorectal disease · 2019Pooled it
- Influence of postoperative complications on long-term outcome after oncologic lung resection surgery. Substudy of a randomized control trial.Journal of clinical monitoring and computing · 2021Trial
- Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery.Intensive care medicine experimental · 2026Article
- Article
- Bayesian Analysis of Postoperative Complication Risk Associated With Preoperative Exposure to Fine Particulate Matter: A Single-Center Cohort Study.Acta anaesthesiologica Scandinavica · 2026Article
- Perioperative Systemic Stress Phenotypes Predict Immune Recovery Failure, Molecular Residual Disease, and Long-Term Outcomes After Colorectal Cancer Surgery: A Prospective Cohort Study.World journal of surgery · 2026Article
- Early postoperative neutrophil to lymphocyte and platelet to lymphocyte ratios predict postoperative complications after curative surgery for locally advanced rectal cancer.Discover oncology · 2026Article
- Addressing methodological limitations in the comparison of robotic surgical stress responses: a call for broader context and enhanced biomarker profiling.International journal of surgery (London, England) · 2026Article
- Construction of prognostic models for colorectal cancer based on the perioperative modified Gustave Roussy Immune Score and machine learning.Frontiers in immunology · 2026Article
- Integrating Preoperative NLR and PLR with Perioperative Clinical Factors: A Nomogram for Predicting Postoperative CRP Elevation After Laparoscopic Hysterectomy.International journal of women's health · 2026Article
- Preoperative risk stratification for postoperative inflammatory-nutritional deterioration after colorectal cancer surgery: an interpretable machine learning study.Frontiers in medicine · 2026Article
- A comparative clinical outcome study of power-assisted vs. manually-operated circular staplers for deep colorectal anastomosis.BMC surgery · 2025Article
- The value of systemic inflammatory response index in evaluating the prognosis of postoperative patients with stage II colon cancer.BMC gastroenterology · 2025Article
- Preoperative albumin-to-fibrinogen ratio as a predictor of postoperative hospital stay in locally advanced esophageal squamous cell carcinoma after neoadjuvant therapy.Scientific reports · 2025Article
- Impact of Low- Versus Standard-Pressure Pneumoperitoneum on Postoperative Recovery in Patients with Obesity Undergoing Robot-Assisted Radical Prostatectomy: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Combined General/Epidural Anesthesia vs. General Anesthesia on Postoperative Cytokines: A Review and Meta-Analysis.Cancers · 2025Review
- Nanotechnology-driven strategies in postoperative cancer treatment: innovations in drug delivery systems.Frontiers in pharmacology · 2025Review
- Combining Preoperative and Postoperative Prognostic Nutritional Index as an Improved Prognostic Factor for Overall Survival in Patients with Colorectal Cancer.Journal of inflammation research · 2025Article
- Anastomotic leakage after resection for rectal cancer and recurrence-free survival in relation to postoperative C-reactive protein levels.International journal of colorectal disease · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study examined the relationship between the magnitude of the postoperative systemic inflammatory response (SIR), the severity of complications, and long-term outcomes following surgery for colorectal cancer.
methodsData were recorded prospectively for patients undergoing potentially curative surgery for colorectal cancer in a single centre between 2008 and 2013. The magnitude of the SIR was measured using C-reactive protein (CRP). Complications were classified by Clavien-Dindo grade. The impact on disease specific and overall survival was assessed using univariate and multivariate Cox regression.
resultsOf 377 patients included, the majority were male (55 %), older than age 65 years (68 %), with colonic (63 %) and node-negative disease (66 %). A total of 138 patients (37 %) had a complication, of which 26 (6 %) were Clavien-Dindo grade 3 or 4 severity. Complication severity was significantly associated with the established CRP thresholds of 150 mg/L on postoperative day (POD) 3 (p < 0.001) and POD 4 (p < 0.001). Median follow-up was 42 months with disease-specific survival 86 % and overall survival 78 %. On univariate analysis, complication severity [hazard ratio (HR) 1.66, 95 % confidence interval (CI) 1.13-2.43, p = 0.009], and POD 4 CRP > 150 mg/L (HR 2.53, 95 % CI 1.43-4.48, p = 0.001) were associated with disease-specific survival. On multivariate survival analysis, POD 4 CRP > 150 mg/L (HR 2.00, 95 % CI 1.12-3.59, p = 0.020), but not complication severity, was significantly associated with disease-specific survival independent of TNM stage (HR 2.46, 95 % CI 1.52-4.12, p < 0.001).
conclusionsThe magnitude of the postoperative SIR, evidenced by CRP, was significantly associated with long-term outcomes following surgery for colorectal cancer, independent of complications and stage.
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