Evidence map›Paper›PMID 27016233›Full record

ReviewGynecologic oncology2016

Leveraging immunotherapy for the treatment of gynecologic cancers in the era of precision medicine.

Dmitriy Zamarin, Amir A Jazaeri

Abstract readReview
In one paragraph

Review in Gynecologic oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Randomized Phase II Trial of Nivolumab Versus Nivolumab and Ipilimumab for Recurrent or Persistent Ovarian Cancer: An NRG Oncology Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Comprehensive analysis of the prognostic value and immune function of theAmerican journal of translational research · 2021
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. AHeliyon · 2017
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dmitriy ZamarinDepartment of Medicine, Gynecologic Medical Oncology Service, Memorial Sloan Kettering Cancer Center, United States.
Amir A JazaeriDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas, MD Anderson Cancer Center, United States. Electronic address: aajazaeri@mdanderson.org.
Memorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

During the past decade significant progress in the understanding of stimulatory and inhibitory signaling pathways in immune cells has reinvigorated the field of immuno-oncology. In this review we outline the current immunotherapy based approaches for the treatment of gynecological cancers, and focus on the emerging clinical data on immune checkpoint inhibitors, adoptive cell therapies, and vaccines. It is anticipated that in the coming years biomarker-guided clinical trials, will provide for a better understanding of the mechanisms of response and resistance to immunotherapy, and guide combination treatment strategies that will extend the benefit from immunotherapy to patients with gynecologic cancers.

Indexed as

ImmunotherapyPrecision MedicineCancer VaccinesCTLA-4 AntigenFemaleGenital Neoplasms, FemaleHumansImmunotherapy, AdoptiveLymphocyte ActivationOncolytic VirotherapyProgrammed Cell Death 1 ReceptorT-LymphocytesCancer VaccinesCTLA-4 AntigenPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCervical cancerCheckpoint inhibitorsEndometrial cancerGynecologic cancersImmuno-oncologyImmunotherapyOvarian cancer

Identifiers

PMID27016233
PMCPMC5007873
OpenAlexW2303325622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.