Evidence map›Paper›PMID 27016231›Full record

ReviewGynecologic oncology2016

Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know.

Joyce Liu, Shannon N Westin

Abstract readReview
In one paragraph

Review in Gynecologic oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joyce LiuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States.
Shannon N WestinDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: swestin@mdanderson.org.

Funding

UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0M
Targeting the PI3K Signaling Pathway in Endometrial CarcinomaP50CA098258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BODURKA, DIANE · 2003 to 2020
$32.0M
Paul Calabresi Clinical Oncology AwardK12CA088084 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI David S. Hong, Scott Kopetz · 2000 to 2026
$14.0M
NCI NIH HHS 2P50CA083639NCI NIH HHS 2P50 CA098258-06NCI NIH HHS K12 CA088084NCI NIH HHS L30 CA189102NCI NIH HHS P50 CA083639NCI NIH HHS P50 CA098258
6 · The paper itself

Abstract

Precision medicine is a rapidly evolving area in the treatment of gynecologic malignancies. Advances in sequencing technology have resulted in an increasing wealth of data regarding the genomic characteristics of ovarian, endometrial, and cervical cancers. These vast new datasets of information have led to novel insights into potential vulnerabilities and therapeutic targets for these cancers. However, unraveling the complex molecular changes within cancer cells to determine how best to attack these targets and to identify effective biomarkers of response remains a significant challenge. In this article, we review the current status of biomarker-driven targeted therapy in gynecologic malignancies.

Indexed as

Biomarkers, TumorFemaleGenes, BRCA1Genes, p53Genital Neoplasms, FemaleHumansImmunotherapyMolecular Targeted TherapyMutationPhosphoinositide-3 Kinase InhibitorsPoly(ADP-ribose) Polymerase InhibitorsPrecision MedicineProto-Oncogene Proteins B-rafBiomarkers, TumorBRAF protein, humanPhosphoinositide-3 Kinase InhibitorsPoly(ADP-ribose) Polymerase InhibitorsProto-Oncogene Proteins B-rafBiomarkersGynecologic cancerPersonalized medicinePrecision medicineTargeted therapy

Identifiers

PMID27016231
PMCPMC4808566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.