ArticleHeadache2016
Severe Headache or Migraine History is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004.
Article in Headache, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.Headache · 2020Pooled it
- Giving Researchers a Headache - Sex and Gender Differences in Migraine.Frontiers in neurology · 2020Pooled it
- The effect of salt substitution on frequency and severity of headache: results from the SSaSS cluster-randomised controlled trial of 20,995 participants.European journal of clinical nutrition · 2024Trial
- Association between milk consumption and migraines among American adults: national health and nutrition examination survey.BMC nutrition · 2025Article
- A summary of the current circumstances of migraineurs in China: a review of the GBD2019 database.Frontiers in human neuroscience · 2025Review
- Association Between Magnesium Intake and Migraine Among Pre and Postmenopausal Women: A Cross-Sectional Study.International journal of women's health · 2025Article
- Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study.Frontiers in nutrition · 2025Article
- Association between serum vitamin D and severe headache or migraine: A population-based analysis.PloS one · 2025Article
- Interaction between diabetes and body mass index on severe headache or migraine in adults: a cross-sectional study.BMC geriatrics · 2024Article
- Associations between the waist-to-height ratio index and migraine: A cross-section study of the NHANES 1999-2004.PloS one · 2024Article
- Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2024Article
- Specifically formulated ketogenic, low carbohydrate, and carnivore diets can prevent migraine: a perspective.Frontiers in nutrition · 2024Article
- Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.Current neurology and neuroscience reports · 2023Review
- Review
- Is there an association between a plant-based eating pattern and clinical findings of a migraine headache?Frontiers in nutrition · 2023Article
- Association between dietary potassium intake and severe headache or migraine in US adults: a population-based analysis.Frontiers in nutrition · 2023Article
- Severe headache trajectory following aneurysmal subarachnoid hemorrhage: the association with lower sodium levels.Brain injury · 2022Article
- Migraine severity, disability, and duration: Is a good diet quality, high intake of phytochemicals and polyphenols important?Frontiers in nutrition · 2022Article
- Secular Trends in the Incidence of Migraine in China from 1990 to 2019: A Joinpoint and Age-Period-Cohort Analysis.Journal of pain research · 2022Article
- Sodium Chloride, Migraine and Salt Withdrawal: Controversy and Insights.Medical sciences (Basel, Switzerland) · 2021Article
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6 authors.
Funding
Abstract
objectiveWe investigated whether dietary sodium intake from respondents of a national cross-sectional nutritional study differed by history of migraine or severe headaches.
backgroundSeveral lines of evidence support a disruption of sodium homeostasis in migraine.
designOur analysis population was 8819 adults in the 1999-2004 National Health and Nutrition Examination Survey (NHANES) with reliable data on diet and headache history. We classified respondents who reported a history of migraine or severe headaches as having probable history of migraine. To reduce the diagnostic conflict from medication overuse headache, we excluded respondents who reported taking analgesic medications. Dietary sodium intake was measured using validated estimates of self-reported total grams of daily sodium consumption and was analyzed as the residual value from the linear regression of total grams of sodium on total calories. Multivariable logistic regression that accounted for the stratified, multistage probability cluster sampling design of NHANES was used to analyze the relationship between migraine and dietary sodium.
resultsOdds of probable migraine history decreased with increasing dietary sodium intake (odds ratio = 0.93, 95% confidence interval = 0.87, 1.00, P = .0455). This relationship was maintained after adjusting for age, sex, and body mass index (BMI) with slightly reduced significance (P = .0505). In women, this inverse relationship was limited to those with lower BMI (P = .007), while in men the relationship did not differ by BMI. We likely excluded some migraineurs by omitting frequent analgesic users; however, a sensitivity analysis suggested little effect from this exclusion.
conclusionsThis study is the first evidence of an inverse relationship between migraine and dietary sodium intake. These results are consistent with altered sodium homeostasis in migraine and our hypothesis that dietary sodium may affect brain extracellular fluid sodium concentrations and neuronal excitability.
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