Evidence map›Paper›PMID 27015816›Full record

ReviewAnnals of biomedical engineering2016

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.

Ghassan S Kassab, Gary An, Edward A Sander, Michael I Miga, Julius M Guccione, Songbai Ji, Yoram Vodovotz

Abstract readReview
In one paragraph

Review in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Agent-based models of inflammation in translational systems biology: A decade later.Wiley interdisciplinary reviews. Systems biology and medicine · 2019
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Ghassan S KassabCalifornia Medical Innovations Institute, San Diego, CA, 92121, USA.
Gary AnDepartment of Surgery, University of Chicago, Chicago, IL, 60637, USA.
Edward A SanderDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
Michael I MigaDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Julius M GuccioneDepartment of Surgery, University of California, San Francisco, CA, 94143, USA.
Songbai JiThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Yoram VodovotzDepartment of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA. vodovotzy@upmc.edu.
California Medical Innovations Institute · USDartmouth College · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Iowa · USUniversity of Pittsburgh · USVanderbilt University · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI ABADIE, VALERIE · 1990 to 2025
$29.8M
Multi-Center Group to Study Acute Liver Failure in ChildU01DK072146 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SQUIRES, ROBERT H · 2005 to 2014
$23.2M
Regulation of Intestinal Mucosal Injury & Repair After Trauma/Hemorrhagic ShockP50GM053789 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VODOVOTZ, YORAM · 1997 to 2013
$18.0M
Multimodal Registration of the Brain's Cortical SurfaceR01NS049251 · NINDS · VANDERBILT UNIVERSITY · PI GOLBY, ALEXANDRA J, MIGA, MICHAEL IAN · 2005 to 2018
$6.7M
Multi-Scale Laws of Myocardial Growth and RemodelingU01HL119578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2014 to 2018
$3.8M
VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERYR01HL077921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO · 2006 to 2015
$3.4M
SYNERGY: The Dartmouth Center for clinical and Translational ScienceKL2TR001088 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$3.3M
Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart FailureR01HL118627 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2013 to 2016
$3.0M
Clinical Translation of Deformation Compensation for Image-Guided Liver SurgeryR01CA162477 · NCI · VANDERBILT UNIVERSITY · PI JARNAGIN, WILLIAM ROBERT, MIGA, MICHAEL IAN · 2011 to 2015
$3.0M
Accumulated white matter fiber strain from repetitive head impacts in contact sportsR01NS092853 · NINDS · WORCESTER POLYTECHNIC INSTITUTE · PI JI, SONGBAI · 2015 to 2018
$1.5M
Adaptive Simulation to Enable Anatomic-scale Agent-basedR01GM115839 · NIGMS · UNIVERSITY OF CHICAGO · PI AN, GARY, MACAL, CHARLES MARTIN · 2015 to 2017
$1.2M
A Biohybrid Device for Regulating Inflammation in SepsisR01GM107231 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GERLACH, JOERG C., VODOVOTZ, YORAM · 2015 to 2017
$1.0M
NCATS NIH HHS KL2 TR001088NCI NIH HHS R01 CA162477NHLBI NIH HHS R01 HL077921NHLBI NIH HHS R01 HL118627NHLBI NIH HHS U01 HL119578NIDDK NIH HHS P30 DK042086NIDDK NIH HHS U01 DK072146NIGMS NIH HHS P50 GM053789NIGMS NIH HHS R01 GM107231NIGMS NIH HHS R01 GM115839NINDS NIH HHS R01 NS049251NINDS NIH HHS R01 NS092853NINDS NIH HHS R21 NS078607NINDS NIH HHS R21 NS087796NINDS NIH HHS R21 NS088781
6 · The paper itself

Abstract

In this era of tremendous technological capabilities and increased focus on improving clinical outcomes, decreasing costs, and increasing precision, there is a need for a more quantitative approach to the field of surgery. Multiscale computational modeling has the potential to bridge the gap to the emerging paradigms of Precision Medicine and Translational Systems Biology, in which quantitative metrics and data guide patient care through improved stratification, diagnosis, and therapy. Achievements by multiple groups have demonstrated the potential for (1) multiscale computational modeling, at a biological level, of diseases treated with surgery and the surgical procedure process at the level of the individual and the population; along with (2) patient-specific, computationally-enabled surgical planning, delivery, and guidance and robotically-augmented manipulation. In this perspective article, we discuss these concepts, and cite emerging examples from the fields of trauma, wound healing, and cardiac surgery.

Indexed as

Computer SimulationPatient-Specific ModelingPrecision MedicineTranslational Research, BiomedicalCardiac Surgical ProceduresHumansWound HealingWounds and InjuriesComputer-aided interventionsComputer aided surgeryHeartInflammationMathematical modelModel-guided surgeryMultiscale modelWound healing

Identifiers

PMID27015816
PMCPMC4983470
OpenAlexW2305267520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.