Evidence map›Paper›PMID 27015801›Full record

Trial reportThorax2016

Nasal high flow oxygen therapy in patients with COPD reduces respiratory rate and tissue carbon dioxide while increasing tidal and end-expiratory lung volumes: a randomised crossover trial.

John F Fraser, Amy J Spooner, Kimble R Dunster, Chris M Anstey, Amanda Corley

3 registry-linked trialsOpen access · hybridAbstract readComparative StudyLetterRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 88 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 7 pooled it
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03466385 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Nasal High Flow Versus Non-Invasive Ventilation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease

TypeinterventionalSponsorEvangelismos HospitalRan2018 to 2021Enrolled498ConditionsChronic Obstructive Pulmonary Disease, Respiratory Failure, Acute Exacerbation CopdArmsNasal High Flow, Non-Invasive Ventilation
NCT03615417 nacompletednot on this mapstarted 2018, after this paper: background citation

Effectiveness of High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia: A Randomised Controlled Trial

TypeinterventionalSponsorErasme University HospitalRan2018 to 2018Enrolled40ConditionsPreoxygenation, Anesthesia, ObesityArmsHigh Flow Nasal Cannula (HFNC), Standard anesthesia FaceMask (FM)
NCT05910788 naunknown statusnot on this mapstarted 2023, after this paper: background citation

High-Flow Nasal Catheter (HFNC) Compared With Conventional Oxygenation During the Perioperative Period of Patients Undergoing Thoracic Surgery.

TypeinterventionalSponsorFederal University of Rio Grande do SulRan2023 to 2024Enrolled90ConditionsThoracic SurgeryArmshigh flow nasal cannula
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 7 syntheses or guidelines pooled it, 199 citations in OpenAlex.

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  15. Hospital Cost Savings for Sequential COPD Patients Receiving Domiciliary Nasal High Flow Therapy.International journal of chronic obstructive pulmonary disease · 2022
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

John F FraserCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia.
Amy J SpoonerCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia.
Kimble R DunsterCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia Biomedical Engineering and Medical Physics, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia.
Chris M AnsteyCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia Intensive Care Unit, Nambour General Hospital, Nambour, Australia.
Amanda CorleyCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Australia.
Prince Charles Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledPatients with COPD using long-term oxygen therapy (LTOT) over 15 h per day have improved outcomes. As inhalation of dry cold gas is detrimental to mucociliary clearance, humidified nasal high flow (NHF) oxygen may reduce frequency of exacerbations, while improving lung function and quality of life in this cohort. In this randomised crossover study, we assessed short-term physiological responses to NHF therapy in 30 males chronically treated with LTOT. LTOT (2-4 L/min) through nasal cannula was compared with NHF at 30 L/min from an AIRVO through an Optiflow nasal interface with entrained supplemental oxygen. Comparing NHF with LTOT: transcutaneous carbon dioxide (TcCO2) (43.3 vs 46.7 mm Hg, p<0.001), transcutaneous oxygen (TcO2) (97.1 vs 101.2 mm Hg, p=0.01), I:E ratio (0.75 vs 0.86, p=0.02) and respiratory rate (RR) (15.4 vs 19.2 bpm, p<0.001) were lower; and tidal volume (Vt) (0.50 vs 0.40, p=0.003) and end-expiratory lung volume (EELV) (174% vs 113%, p<0.001) were higher. EELV is expressed as relative change from baseline (%Δ). Subjective dyspnoea and interface comfort favoured LTOT. NHF decreased TcCO2, I:E ratio and RR, with a concurrent increase in EELV and Vt compared with LTOT. This demonstrates a potential mechanistic rationale behind the improved outcomes observed in long-term treatment with NHF in oxygen-dependent patients. TRIAL REGISTRATION NUMBER: ACTRN12613000028707.

Indexed as

Oxygen Inhalation TherapyRespiratory RateTidal VolumeCarbon DioxideCohort StudiesCross-Over StudiesHumansLong-Term CareMaleOximetryPeak Expiratory Flow RatePositive-Pressure RespirationPulmonary Disease, Chronic ObstructiveQuality of LifeCarbon DioxideCOPD ExacerbationsLong Term Oxygen Therapy (LTOT)Non invasive ventilation

Identifiers

PMID27015801
PMCPMC4975837
OpenAlexW2311793624

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.