ArticleNanomedicine : nanotechnology, biology, and medicine2016
Direct detection of malaria infected red blood cells by surface enhanced Raman spectroscopy.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- The application of spectroscopy techniques for diagnosis of malaria parasites and arboviruses and surveillance of mosquito vectors: A systematic review and critical appraisal of evidence.PLoS neglected tropical diseases · 2021Pooled it
- Enhanced detection of malaria infected red blood cells through phase driven classification.Scientific reports · 2025Article
- A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites.The Analyst · 2023Article
- Automated wide-field malaria parasite infection detection using Fourier ptychography on stain-free thin-smears.Biomedical optics express · 2022Article
- Discriminant Analysis PCA-LDA Assisted Surface-Enhanced Raman Spectroscopy for Direct Identification of Malaria-Infected Red Blood Cells.Methods and protocols · 2022Article
- Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.PLoS pathogens · 2021Article
- Confocal Raman Spectral Imaging Study of DAPT, a γ-secretase Inhibitor, Induced Physiological and Biochemical Reponses in Osteosarcoma Cells.International journal of medical sciences · 2020Article
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Ag Nanorods-Based Surface-Enhanced Raman Scattering: Synthesis, Quantitative Analysis Strategies, and Applications.Frontiers in chemistry · 2019Review
- Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review.Applied spectroscopy · 2018Review
- Raman characterizations of red blood cells with β-thalassemia using laser tweezers Raman spectroscopy.Medicine · 2018Article
- Image analysis and machine learning for detecting malaria.Translational research : the journal of laboratory and clinical medicine · 2018Review
- A pilot study on fingerprinting Leishmania species from the Old World using Fourier transform infrared spectroscopy.Analytical and bioanalytical chemistry · 2017Article
- Recent Progress in the Development of Diagnostic Tests for Malaria.Diagnostics (Basel, Switzerland) · 2017Review
- Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma.Lipids in health and disease · 2017Article
- Fabrication of gold-coated PDMS surfaces with arrayed triangular micro/nanopyramids for use as SERS substrates.Beilstein journal of nanotechnology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Surface enhanced Raman spectra (SERS) of normal red blood cells (RBCs) and Plasmodium falciparum infected RBCs (iRBCs) at different post invasion time were obtained based on silver nanorod array substrates. Distinct spectral differences were observed due to the cell membrane modification of RBCs during malaria infection. The SERS spectra of ring stage iRBCs had a characteristic Raman peak at Δv=1599cm(-1) as compared to those of normal RBCs, while the trophozoite and schizoid stages had identical SERS spectra with a characteristic peak at Δv=723cm(-1), which is significantly different from ring stage iRBCs, consistent with ongoing modification of the iRBC membrane. Since ring stage iRBCs of P. falciparum are found circulating in blood, such a difference provides a new strategy for rapid malaria detection. The limit of detection as well as the ability to detect a mixed iRBC and RBC solution was also investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.