ArticlePLoS neglected tropical diseases2016
Prevalence and Genotype Allocation of Pathogenic Leptospira Species in Small Mammals from Various Habitat Types in Germany.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic review of leptospirosis on wild animals in Latin America.Tropical animal health and production · 2018Pooled it
- Small rodents, huge impact: A scoping review of EuropeanOne health (Amsterdam, Netherlands) · 2026Review
- Wild Boar (Animals : an open access journal from MDPI · 2026Article
- Serological and molecular evidence of Leptospira spp. in martens from Poland.BMC veterinary research · 2026Article
- Tracking potentialOne health (Amsterdam, Netherlands) · 2024Article
- Genotyping ofFrontiers in microbiology · 2024Article
- Leptospirosis and the Environment: A Review and Future Directions.Pathogens (Basel, Switzerland) · 2023Review
- White-Toothed Shrews (GenusPathogens (Basel, Switzerland) · 2023Article
- Non-Invasive Wildlife Disease Surveillance Using Real Time PCR Assays: The Case of the EndangeredAnimals : an open access journal from MDPI · 2023Article
- Synanthropic and Wild Animals as Sentinels of Zoonotic Agents: A Study ofInternational journal of environmental research and public health · 2023Article
- Molecular detection of Leptospira spp. in small wild rodents from rural areas of São Paulo State, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Occurrence ofMicroorganisms · 2022Article
- Article
- Molecular Typing of PathogenicAnimals : an open access journal from MDPI · 2021Article
- Environmental Exposure of Wild Carnivores to Zoonotic Pathogens:International journal of environmental research and public health · 2021Article
- Hantavirus-Epidemiology and infection · 2021Article
- Wild rodents and insectivores as carriers of pathogenic Leptospira and Toxoplasma gondii in The Netherlands.Veterinary medicine and science · 2020Article
- Spatio-temporal trends in richness and persistence of bacterial communities in decline-phase water vole populations.Scientific reports · 2020Article
- Survival time of Leptospira kirschneri serovar Grippotyphosa under different environmental conditions.PloS one · 2020Article
- Small Mammals as Carriers/Hosts ofFrontiers in veterinary science · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small mammals serve as most important reservoirs for Leptospira spp., the causative agents of Leptospirosis, which is one of the most neglected and widespread zoonotic diseases worldwide. The knowledge about Leptospira spp. occurring in small mammals from Germany is scarce. Thus, this study's objectives were to investigate the occurrence of Leptospira spp. and the inherent sequence types in small mammals from three different study sites: a forest in southern Germany (site B1); a National Park in south-eastern Germany (site B2) and a renaturalised area, in eastern Germany (site S) where small mammals were captured. DNA was extracted from kidneys of small mammals and tested for Leptospira spp. by real-time PCR. Positive samples were further analysed by duplex and conventional PCRs. For 14 positive samples, multi locus sequence typing (MLST) was performed. Altogether, 1213 small mammals were captured: 216 at site B1, 456 at site B2 and 541 at site S belonging to following species: Sorex (S.) araneus, S. coronatus, Apodemus (A.) flavicollis, Myodes glareolus, Microtus (Mi.) arvalis, Crocidura russula, Arvicola terrestris, A. agrarius, Mustela nivalis, Talpa europaea, and Mi. agrestis. DNA of Leptospira spp. was detected in 6% of all small mammals. At site B1, 25 small mammals (11.6%), at site B2, 15 small mammals (3.3%) and at site S, 33 small mammals (6.1%) were positive for Leptospira spp. Overall, 54 of the positive samples were further determined as L. kirschneri, nine as L. interrogans and four as L. borgpetersenii while five real-time PCR-positive samples could not be further determined by conventional PCR. MLST results revealed focal occurrence of L. interrogans and L. kirschneri sequence type (ST) 117 while L. kirschneri ST 110 was present in small mammals at all three sites. Further, this study provides evidence for a particular host association of L. borgpetersenii to mice of the genus Apodemus.
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