ArticlePloS one2016
Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Differential roles of insulin receptor in adipocyte progenitor cells in mice.Molecular and cellular endocrinology · 2023Article
- Inflammation and metabolism gene sets in subcutaneous abdominal adipose tissue are altered 1 hour after exercise in adults with obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo.PloS one · 2021Article
- The Effects of Exercise on White and Brown Adipose Tissue Cellularity, Metabolic Activity and Remodeling.Frontiers in physiology · 2021Review
- Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors.Frontiers in cell and developmental biology · 2020Review
- The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function.Stem cell research & therapy · 2019Review
- Article
- Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis.Trends in endocrinology and metabolism: TEM · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Exercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitors, we show that these cells react to exercise by decreasing their proliferation and differentiation potential. Analyses of mouse models that mimic the skeletal muscle adaptation to exercise indicate that muscle, in a non-autonomous manner, regulates adipose progenitor homeostasis, highlighting a role for muscle-derived secreted factors. These findings support a humoral link between skeletal muscle and adipose progenitors and indicate that manipulation of adipose stem cell function may help address obesity and diabetes.
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Registered trials
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