Evidence map›Paper›PMID 27015411›Full record

ArticlePloS one2016

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila.

Ying-Ju Chang, Lily Zhou, Richard Binari, Armen Manoukian, Tak Mak, Helen McNeill, Vuk Stambolic

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ying-Ju ChangPrincess Margaret Cancer Center/University Health Network, Toronto, Ontario, Canada.
Lily ZhouPrincess Margaret Cancer Center/University Health Network, Toronto, Ontario, Canada.
Richard BinariPrincess Margaret Cancer Center/University Health Network, Toronto, Ontario, Canada.
Armen ManoukianPrincess Margaret Cancer Center/University Health Network, Toronto, Ontario, Canada.
Tak MakPrincess Margaret Cancer Center/University Health Network, Toronto, Ontario, Canada.
Helen McNeillLunenfeld-Tanenbaum Research Institute/Mount Sinai Hospital, Toronto, Ontario, Canada.
Vuk StambolicPrincess Margaret Cancer Center/University Health Network, Toronto, Ontario, Canada.
University Health Network · CAPrincess Margaret Cancer Centre · CAMount Sinai Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The insulin/IGF-1 signaling pathway mediates various physiological processes associated with human health. Components of this pathway are highly conserved throughout eukaryotic evolution. In Drosophila, the PTEN ortholog and its mammalian counterpart downregulate insulin/IGF signaling by antagonizing the PI3-kinase function. From a dominant loss-of-function genetic screen, we discovered that mutations of a Dbl-family member, the guanine nucleotide exchange factor DRhoGEF2 (DRhoGEF22(l)04291), suppressed the PTEN-overexpression eye phenotype. dAkt/dPKB phosphorylation, a measure of PI3K signaling pathway activation, increased in the eye discs from the heterozygous DRhoGEF2 wandering third instar larvae. Overexpression of DRhoGEF2, and it's functional mammalian ortholog PDZ-RhoGEF (ArhGEF11), at various stages of eye development, resulted in both dPKB/Akt-dependent and -independent phenotypes, reflecting the complexity in the crosstalk between PI3K and Rho signaling in Drosophila.

Indexed as

AnimalsCell Cycle ProteinsDrosophilaDrosophila ProteinsEyeGene Expression Regulation, DevelopmentalHumansInsulinInsulin-Like Growth Factor IMutationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrho GTP-Binding ProteinsSignal TransductionCell Cycle ProteinsDrosophila ProteinsInsulinInsulin-Like Growth Factor IPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrho GTP-Binding Proteinssav protein, Drosophila

Identifiers

PMID27015411
PMCPMC4807833
OpenAlexW2303498328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.