Observational studyMedicine2016
Oxidative Stress and Periodontal Disease in Obesity.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses.Clinical oral investigations · 2021Pooled it
- Obesity as a Determinant of Periodontal Therapy Outcomes: Insights on Oxidative and Endoplasmic Reticulum Stress Pathways.International dental journal · 2026Article
- Association between Pediatric Obesity and Periodontal Health: A Systematic Review.International journal of clinical pediatric dentistry · 2026Review
- The research progress on periodontitis by the National Natural Science Foundation of China.International journal of oral science · 2025Review
- Association of Chronic Periodontitis with Hemorrhagic Stroke: A Systematic Review and Meta-Analysis.European journal of dentistry · 2025Article
- Assessment of Total Antioxidant Capacity and Malondialdehyde Levels in Obese Patients With Periodontitis.Cureus · 2024Article
- Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.NPJ biofilms and microbiomes · 2024Article
- The rosetta stone of successful ageing: does oral health have a role?Biogerontology · 2023Review
- Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota.International journal of molecular sciences · 2023Article
- Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2023Review
- Obesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers.Clinical oral investigations · 2023Article
- The impact of dental metal restorations on the oral oxidative stress level.Journal of clinical and experimental dentistry · 2023Article
- Periodontal Health and Disease in the Context of Systemic Diseases.Mediators of inflammation · 2023Review
- Periodontal Therapy in Bariatric Surgery Patients with Periodontitis: Randomized Control Clinical Trial.Journal of clinical medicine · 2022Article
- Periodontal and Hepatic Parameters in Obese Patients Undergoing Bariatric Surgery.Oral health & preventive dentistry · 2022Article
- A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey.BMC oral health · 2021Article
- Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis.Periodontology 2000 · 2021Review
- Saliva pH and Flow Rate in Patients with Periodontal Disease and Associated Cardiovascular Disease.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Association between metabolic and hormonal profile, proinflammatory cytokines in saliva and gingival health in adolescent females with polycystic ovary syndrome.BMC oral health · 2021Article
- The Influence of Diet on Oxidative Stress and Inflammation Induced by Bacterial Biofilms in the Human Oral Cavity.Materials (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is a chronic inflammatory disease of the jaws and is more prevalent in obesity. Local and systemic oxidative stress may be an early link between periodontal disease and obesity. The primary aim of this study was to detect whether increased periodontal disease susceptibility in obese individuals is associated with local and systemic oxidative stress. Accordingly; we analyzed periodontal status and systemic (serum) and local (gingival crevicular fluid [GCF]) oxidative status markers in young obese women in comparison with age-matched lean women.Twenty obese and 20 lean women participated. Periodontal condition was determined by clinical periodontal indices including probing depth, clinical attachment level, gingival index, gingival bleeding index, and plaque index. Anthropometric, hormonal, and metabolic measurements were also performed. Blood and GCF sampling was performed at the same time after an overnight fasting. Serum and GCF total antioxidant capacity (TAOC), and total oxidant status (TOS) levels were determined, and oxidative stress index (OSI) was calculated.Clinical periodontal analyses showed higher gingival index and gingival bleeding index in the obese group (P = 0.001 for both) with no significant difference in probing depth, clinical attachment level, and plaque index between the obese and the lean women. Oxidant status analyses revealed lower GCF and serum TAOC, and higher GCF and serum OSI values in the obese women (P < 0.05 for all). GCF TOS was higher in the obese women (P < 0.05), whereas there was a nonsignificant trend for higher serum TOS in obese women (P = 0.074). GCF TAOC values showed a negative correlation with body mass index, whereas GCF OSI was positively correlated with fasting insulin and low-density lipoprotein-cholesterol levels (P < 0.05 for all). Clinical periodontal indices showed significant correlations with body mass index, insulin, and lipid levels, and also oxidant status markers.Our results suggest that young obese, otherwise healthy, women show findings of early periodontal disease (gingival inflammation) compared with age-matched healthy lean women, and that local/periodontal oxidative stress generated by obesity seems to be associated with periodontal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.