Observational studyMedicine2016
Cardiovascular Autonomic Dysfunction Predicts Diabetic Foot Ulcers in Patients With Type 2 Diabetes Without Diabetic Polyneuropathy.
Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Global Epidemiology of Diabetic Foot: A Systematic Review and Meta-Analysis.Diabetes/metabolism research and reviews · 2026Pooled it
- Prediction of Factors Influencing the Incidence of Diabetic Foot Ulcers Using Classical Statistical and Machine Learning Approaches: A Systematic Review.International wound journal · 2026Pooled it
- Risk Factors for First-Ever Diabetes-Related Foot Ulcer: A Systematic Review and Meta-Analysis.International wound journal · 2025Pooled it
- Incidence and risk factors for amputation in Chinese patients with diabetic foot ulcers: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Comparison of Heart Rate Variability in People With Diabetes-Related Neuropathic Foot to Their Counterparts Without a Foot Ulcer History: A Propensity Score Matching Study.Journal of diabetes research · 2025Article
- The role of diabetic foot treatment in improving left ventricular function: Insights from global longitudinal strain echocardiography.PloS one · 2024Article
- KADAM topical warm oxygen therapy device for diabetic foot ulcer-a novel approach.Journal of diabetes and metabolic disorders · 2023Article
- Mortality in Patients with Diabetic Foot Ulcers: Causes, Risk Factors, and Their Association with Evolution and Severity of Ulcer.Journal of clinical medicine · 2020Article
- Changes in Foot Skin Microbiome of Patients with Diabetes Mellitus Using High-Throughput 16S rRNA Gene Sequencing: A Case Control Study from a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Evaluation of Factors Affecting the Severity of Diabetic Foot Ulcer in Patients with Diabetes Referred to a Diabetes Centre in Kermanshah.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Article
- The Diabetic Foot as a Proxy for Cardiovascular Events and Mortality Review.Current atherosclerosis reports · 2017Review
- Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study.Experimental gerontology · 2017Article
- Cardiac Autonomic Neuropathy Predicts All-Cause and Cardiovascular Mortality in Patients With End-Stage Renal Failure: A 5-Year Prospective Study.Kidney international reports · 2017Article
- Analysis of the association between glucose profiles and β-cell function for diabetic cardiovascular autonomic neuropathy in China.Journal of diabetes investigation · 2017Article
- Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Review
- Strong association of anemia in people with diabetic foot ulcers (DFUs): Study from a specialist foot care center.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the factors that might influence the development of diabetic foot ulcers (DFUs) in type 2 diabetes patients without diabetic polyneuropathy (DPN).From January 2000 to December 2005, a total of 595 patients who had type 2 diabetes without DPN between the ages of 25 and 75 years, and had no prior history of DFUs were consecutively enrolled in the study. A cardiovascular autonomic function test was performed to diagnose cardiovascular autonomic neuropathy (CAN) using heart rate variability parameters.The median follow-up time was 13.3 years. Among the 449 (75.4%) patients who completed the follow-up evaluation, 22 (4.9%) patients developed new ulcers, and 6 (1.3%) patients underwent the procedure for lower extremity amputations. The patients in the DFUs group had a longer duration of diabetes, higher baseline HbA1c levels, higher rates of nephropathy, and CAN. A Cox hazard regression analysis results revealed that the development of DFUs was significantly associated with the presence of CAN (normal vs definite CAN; HR, 4.45; 95% confidence interval, 1.29-15.33) after adjusting for possible confounding factors.The development of DFUs was independently associated with CAN in patients with type 2 diabetes without DPN. We suggested the importance of CAN as a predictor of DFUs even in the patients without DPN, and the need to pay attention to patients with definite CAN and type 2 diabetes.
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