ArticleAnnals of the American Thoracic Society2016
Pulmonary Morbidity in Infancy after Exposure to Chorioamnionitis in Late Preterm Infants.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Plasma proteomic signature of neonates in the context of placental histological chorioamnionitis.BMJ paediatrics open · 2024Article
- Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response.Frontiers in immunology · 2023Article
- Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates.Science translational medicine · 2022Article
- Chorioamnionitis and neonatal outcomes.Pediatric research · 2022Review
- Prenatal Maternal Lipopolysaccharide and Mild Newborn Hyperoxia Increase Intrapulmonary Airway but Not Vessel Reactivity in a Mouse Model.Children (Basel, Switzerland) · 2021Article
- Medication Utilization at School Age for Children Born Preterm.The Journal of pediatrics · 2020Article
- Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms.Frontiers in immunology · 2020Review
- DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis.Frontiers in pediatrics · 2020Article
- Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.Frontiers in immunology · 2020Review
- Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates.Scientific reports · 2019Article
- Tidal Breathing Measurements at Discharge and Clinical Outcomes in Extremely Low Gestational Age Neonates.Annals of the American Thoracic Society · 2018Article
- Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018Article
- Early Life Wildfire Smoke Exposure Is Associated with Immune Dysregulation and Lung Function Decrements in Adolescence.American journal of respiratory cell and molecular biology · 2017Article
- Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleChorioamnionitis is an important cause of preterm birth, but its impact on postnatal outcomes is understudied.
objectivesTo evaluate whether fetal exposure to inflammation is associated with adverse pulmonary outcomes at 6 to 12 months' chronological age in infants born moderate to late preterm.
methodsInfants born between 32 and 36 weeks' gestational age were prospectively recruited (N = 184). Chorioamnionitis was diagnosed by placenta and umbilical cord histology. Select cytokines were measured in samples of cord blood. Validated pulmonary questionnaires were administered (n = 184), and infant pulmonary function testing was performed (n = 69) between 6 and 12 months' chronological age by the raised volume rapid thoracoabdominal compression technique. MEASUREMENTS AND MAIN
resultsA total of 25% of participants had chorioamnionitis. Although infant pulmonary function testing variables were lower in infants born preterm compared with historical normative data for term infants, there were no differences between infants with chorioamnionitis (n = 20) and those without (n = 49). Boys and black infants had lower infant pulmonary function testing measurements than girls and white infants, respectively. Chorioamnionitis exposure was associated independently with wheeze (odds ratio [OR], 2.08) and respiratory-related physician visits (OR, 3.18) in the first year of life. Infants exposed to severe chorioamnionitis had increased levels of cord blood IL-6 and greater pulmonary morbidity at age 6 to 12 months than those exposed to mild chorioamnionitis. Elevated IL-6 was associated with significantly more respiratory problems (OR, 3.23).
conclusionsIn infants born moderate or late preterm, elevated cord blood IL-6 and exposure to histologically identified chorioamnionitis was associated with respiratory morbidity during infancy without significant changes in infant pulmonary function testing measurements. Black compared with white and boy compared with girl infants had lower infant pulmonary function testing measurements and worse pulmonary outcomes.
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