ArticleEndocrinology2016
Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop.
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Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
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Who cites it
36 citing papers in PubMed, 79 citations in OpenAlex.
- BPA Disrupts Hepatic Lipid and Carbohydrate Metabolism in Female Zebrafish: Protective Effects of Probiotics Revealed by FTIRI and Lipidomics.International journal of molecular sciences · 2026Article
- Ancestral bisphenol A exposure led to non-alcoholic fatty liver disease and sex-specific alterations in proline and bile metabolism pathways in the liver.Environmental toxicology and chemistry · 2025Article
- Delineating lipidomic landscapes in human and mouse ovaries: Spatial signatures and chemically-induced alterations via MALDI mass spectrometry imaging: Spatial ovarian lipidomics.Environment international · 2024Article
- Endocannabinoid System and Metabolism: The Influences of Sex.International journal of molecular sciences · 2024Review
- Investigating the modulation of the endocannabinoid system by probiotic Lactiplantibacillus plantarum IMC513 in a zebrafish model of di-n-hexyl phthalate exposure.Scientific reports · 2024Article
- Evaluation of Lipids and Lipid-Related Transcripts in Human and Ovine Theca Cells and anEnvironmental health perspectives · 2024Article
- The effects of environmental changes on the endocrine regulation of feeding in fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies.International journal of molecular sciences · 2024Review
- A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation.International journal of molecular sciences · 2023Article
- Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants-A Review.International journal of molecular sciences · 2023Review
- Article
- Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use.Molecules (Basel, Switzerland) · 2022Review
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- Obesity II: Establishing causal links between chemical exposures and obesity.Biochemical pharmacology · 2022Review
- Article
- Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.International journal of molecular sciences · 2022Review
- Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review.International journal of molecular sciences · 2021Review
- Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells.International journal of molecular sciences · 2021Article
- Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγ.Cell biology and toxicology · 2021Article
- Bisphenol A Deranges the Endocannabinoid System of Primary Sertoli Cells with an Impact on Inhibin B Production.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Andrea MartellaDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Cristoforo SilvestriDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Francesca MaradonnaDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Giorgia GioacchiniDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Marco AllaràDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Giuseppe RadaelliDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Darryl R OverbyDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Vincenzo Di MarzoDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Oliana CarnevaliDipartimento di Scienze della Vita e dell'Ambiente (A.M., F.M., G.G., O.C.), Università Politecnica delle Marche, 60131 Ancona, Italy; Endocannabinoid Research Group (A.M., C.S., M.A., V.D.), Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy; Dipartimento di Biomedicina Comparata e Alimentazione (G.R.), Universitá degli Studi di Padova, 35020 Legnaro (PD), Italy; Department of Bioengineering (C.S., D.R.O.), Imperial College London, London SW7 2AZ, United Kingdom; and Istituto Nazionale Biostrutture e Biosistemi (F.M., O.C.), 00136, Roma, Italy.
Imperial College London · GBIstituto Nazionale Biostrutture e Biosistemi · ITMarche Polytechnic University · ITUniversity of Padua · IT
Funding
Mechanisms of developmental toxicity of Bisphenol-AR01ES008314 · NIEHS · TUFTS UNIVERSITY BOSTON · PI SOTO, ANA · 1996 to 2016
$6.8MNIEHS NIH HHS R01 ES008314
Abstract
The xenoestrogen bisphenol A (BPA) is a widespread plasticizer detectable within several ecosystems. BPA is considered a metabolic disruptor, affecting different organs; however, little is known about its mechanism of action in the liver, in which it triggers triglyceride accumulation. Adult zebrafish (Danio rerio) exposed to BPA developed hepatosteatosis, which was associated with an increase in the liver levels of the obesogenic endocannabinoids 2-arachidonoylglycerol and anandamide and a concomitant decrease in palmitoylethanolamide. These changes were associated with variations in the expression of key endocannabinoid catabolic and metabolic enzymes and an increase in the expression of the endocannabinoid receptor cnr1. Acute and chronic in vitro treatments with nano- and micromolar BPA doses showed increased anandamide levels in line with decreased activity of fatty acid amide hydrolase, the main anandamide hydrolytic enzyme, and induced triglyceride accumulation in HHL-5 cells in a CB1-dependent manner. We conclude that BPA is able to produce hepatosteatosis in zebrafish and human hepatocytes by up-regulating the endocannabinoid system.
Indexed as
Benzhydryl CompoundsEndocrine DisruptorsPhenolsAmidesAnimalsArachidonic AcidsBisphenol A CompoundsCell LineEndocannabinoidsEthanolaminesFatty LiverFeedback, PhysiologicalGlyceridesHepatocytesHumansLiverAmidesanandamideArachidonic AcidsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCnr1 protein, zebrafishEndocannabinoidsEndocrine DisruptorsEthanolaminesGlyceridesglyceryl 2-arachidonatepalmidrolPalmitic AcidsPhenolsPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1TriglyceridesZebrafish Proteins
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