ArticlePloS one2016
A Piece of the Puzzle: The Bone Health Index of the BoneXpert Software Reflects Cortical Bone Mineral Density in Pediatric and Adolescent Patients.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Revisiting the radiographic assessment of osteoporosis-Osteopenia in children 0-2 years of age. A systematic review.PloS one · 2020Pooled it
- The effect of vitamin D supplementation and nutritional intake on skeletal maturity and bone health in socio-economically deprived children.European journal of nutrition · 2021Trial
- Can digital X-ray radiogrammetry be an alternative for dual-energy X-ray absorptiometry in the diagnosis of secondary low bone quality in children?European journal of pediatrics · 2019Trial
- Current applications and challenges of artificial intelligence applied to diagnostics in pediatric musculoskeletal imaging.Pediatric radiology · 2026Review
- Real-World Efficacy of Weekly Somatrogon on Growth and Bone Health in Pediatric Growth Hormone Deficiency: A 12-Month Retrospective Cohort StudyJournal of clinical research in pediatric endocrinology · 2026Article
- Longitudinal course of bone health from infancy to mid-adulthood in preterm and term-born individuals.Scientific reports · 2025Article
- Hand X-ray metrics for assessing bone health and fracture risk in Duchenne muscular dystrophy: a cross-sectional study.European journal of pediatrics · 2025Article
- Comparative analysis of an automated bone age tool with manual assessment in a multiethnic Southeast Asian paediatric cohort in Singapore.Pediatric radiology · 2025Article
- Comparison of BoneXpert and IB-Lab-PANDA automated Bone Age Evaluation in Children With Growth and Puberty Disorders.Journal of the Endocrine Society · 2025Article
- Cortical bone status and its determinants in pediatric Klinefelter syndrome.Endocrine connections · 2025Article
- Article
- Bone health in childhood low-grade glioma: an understudied problem.Endocrine connections · 2024Article
- Description of bone health in adolescents and young persons with Klinefelter syndrome - results from a pilot study.Molecular and cellular pediatrics · 2024Article
- The assessment of bone health in children with juvenile idiopathic arthritis; comparison of different imaging-based methods.Pediatric rheumatology online journal · 2024Article
- Article
- Does ethnicity influence bone health index in children? A pilot study.Pediatric radiology · 2024Article
- BoneXpert-derived bone health index reference curves constructed on healthy Indian children and adolescents.Pediatric radiology · 2024Article
- Bone health in children with Angelman syndrome at the ENCORE Expertise Center.European journal of pediatrics · 2024Article
- Hyperphagia, Growth, and Puberty in Children with Angelman Syndrome.Journal of clinical medicine · 2023Article
- Current and emerging artificial intelligence applications for pediatric musculoskeletal radiology.Pediatric radiology · 2022Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSuspected osteopathology in chronically ill children often necessitates the assessment of bone mineral density. The most frequently used methods are dual-energy X-ray-absorption (DXA) and peripheral quantitative computed tomography (pQCT). The BoneXpert software provides an automated radiogrammatic method to assess skeletal age from digitalized X-rays of the left hand. Furthermore, the program calculates the Bone Health Index (BHI), a measure of cortical thickness and mineralization, which is obtained from indices of three metacarpal bones. In our study, we analyzed the manner in which BHI information provided by BoneXpert compares with DXA or pQCT measurements in youths. STUDY
designThe BHI was retrospectively obtained using digitalized X-rays of the left hand and compared with the results of 203 corresponding DXA readings (Lunar Prodigy, GE Healthcare) of the lumbar vertebrae and femur as well as 117 pQCT readings (XCT 900, Stratec) of the distal radius.
resultsThe BHI values showed a strong positive correlation with the DXA readings at each and all lumbar vertebrae (L1 -L4: r = 0.73; P < 0.0001). The age-adjusted Z-score of L1 -L4 and the height-adjusted score showed a positive correlation with the BHI-SDS (standard deviation score, r = 0.23; P < 0.002 and r = 0.27; P < 0.001, respectively). Total bone mineral density, as assessed via pQCT, also positively correlated with the BHI (r = 0.39; P < 0.0001), but the trabecular values displayed only a weak correlation.
conclusionsThe BHI obtained using BoneXpert can be a useful parameter in the assessment of bone health in children in most cases. This technique provides observer-independent information on cortical thickness and mineralization based on X-ray imaging of the hands.
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