Evidence map›Paper›PMID 27014666›Full record

ArticleFrontiers in pediatrics2016

Asthma Control Test and Bronchial Challenge with Exercise in Pediatric Asthma.

Salvatore Tripodi, Mario Barreto, Andrea Di Rienzo-Businco, Oriano Grossi, Ifigenia Sfika, Giovanni Ragusa, Martina Campisano, Stefano Miceli-Sopo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Salvatore TripodiAllergy Pediatric Unit, Pediatrics Department, Sandro Pertini Hospital , Rome , Italy.
Mario BarretoNESMOS Department, Faculty of Medicine and Psychology, Pediatric Unit Sant'Andrea Hospital, "Sapienza" University , Rome , Italy.
Andrea Di Rienzo-BusincoAllergy Pediatric Unit, Pediatrics Department, Sandro Pertini Hospital , Rome , Italy.
Oriano GrossiAllergy Pediatric Unit, Pediatrics Department, Sandro Pertini Hospital , Rome , Italy.
Ifigenia SfikaAllergy Pediatric Unit, Pediatrics Department, Sandro Pertini Hospital , Rome , Italy.
Giovanni RagusaAllergy Pediatric Unit, Pediatrics Department, Sandro Pertini Hospital , Rome , Italy.
Martina CampisanoNESMOS Department, Faculty of Medicine and Psychology, Pediatric Unit Sant'Andrea Hospital, "Sapienza" University , Rome , Italy.
Stefano Miceli-SopoPediatrics Department, Catholic University of Rome , Rome , Italy.
Ospedale Sandro Pertini · ITAzienda Ospedaliera Sant'Andrea · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor asthma control can lead to exercise-induced bronchoconstriction (EIB), but the relationship between subjective disease control and EIB is unclear. No studies have compared asthma control test (ACT) scores of children with those of their parents regarding EIB. We assessed whether ACT scores predict the occurrence of EIB in two age groups. We also evaluated ACT scores and objective measures as explanatory variables for airway response to exercise.

methodsPatients (71, aged <12 years; 93, aged ≥12 years) and their parents completed an ACT questionnaire separately. Current therapy, skin prick testing, and spirometry at baseline and after exercise were assessed. EIB was defined as a fall in forced expiratory volume in 1 s (FEV1) of at least 12% from baseline. Sensitivity and specificity for cut-off values of ACT scores predictive of EIB were plotted, and the area under curve (AUC) was described.

resultsAtopy and current therapy were similarly frequent. EIB was observed in 23.9% of children aged <12 years and in 33.3% of children aged ≥12 years. EIB occurrence in subjects previously scored as having full control (25), partial control (20-24), and no control (<20) varied according to the age group and responders. Percentages of EIB cases increased as ACT scores decreased in children aged ≥12 years alone (child ACT scores, 25: 21.9%, 20-24: 31.1%, <20: 62.5%, p = 0.017). Plots for ACT scores as predictors of EIB yielded low non-significant AUC values in children aged <12 years; in contrast, moderate AUC values emerged in children aged ≥12 years (child: 0.67, p = 0.007; parent: 0.69, p = 0.002). Sensitivity of ACT scores below 20 as a predictor of EIB was low in older children (child: 32.3%, parent: 22.6%), whereas specificity was high (child: 90.3%, parent: 93.5%). Multiple regression analysis with percent fall in FEV1 as dependent variable included FEV1/FVC%, ACT child score, and gender in the prediction model (r = 0.42, p = 0.000).

conclusionACT scores are a more effective means of excluding than confirming EIB in asthmatic patients aged ≥12 years; their predictive value decreases in younger patients. ACT scores together with lung function may help to predict airway response to exercise. New tools for pediatric asthma assessment may optimize this association.

Indexed as

asthma control testatopychildrenexercise-induced bronchoconstrictionlung functionparentsquestionnaires

Identifiers

PMID27014666
PMCPMC4782564
OpenAlexW2320063335

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.