An HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses.

Mehdi Mahdavi, Massoumeh Ebtekar, Zuhair Mohammad Hassan, Sobhan Faezi, Hamidreza Khorram Khorshid, Morteza Taghizadeh, Keyhan Azadmanesh

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Article in International journal of molecular and cellular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Mehdi MahdaviDepartment of Immunology, Pasteur Institute of Iran, Tehran, Iran.

Massoumeh EbtekarDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Zuhair Mohammad HassanDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Sobhan FaeziDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

Hamidreza Khorram KhorshidGenetics Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Morteza TaghizadehDepartment of Medical Virology, Razi Vaccine and Serum Research Institute, Karaj, Iran.

Keyhan AzadmaneshDepartment of Virology, Pasteur Institute of Iran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determine long-lived memory, immune responses were monitored for 20 weeks after final immunization. The results showed that the candidate vaccine induced proliferation and cytotoxic T lymphocyte responses and shifted cytokine patterns to T helper-1 profile. Evaluation of humoral immune responses also showed an increase in total peptide specific-IgG titer and a shift to IgG2a humoral response. Monitoring of immune responses at weeks 4, 12 and 20 after last immunization showed that immunologic parameters have been sustained for 20 weeks. Our findings support the notion that long-lived memory responses were achieved using a mini vaccine immunization.

Indexed as

BALB/c miceHIV-1long-lived immune responsesP24-Nef fusion peptide

Identifiers

PMID27014646

PMCPMC4769599

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