ArticleFrontiers in microbiology2016
The IncP-6 Plasmid p10265-KPC from Pseudomonas aeruginosa Carries a Novel ΔISEc33-Associated bla KPC-2 Gene Cluster.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance inInternational journal of molecular sciences · 2023Pooled it
- Investigating the prevalence of KPC-2 and the variant KPC-144 in carbapenem-resistant Klebsiella pneumoniae and elucidating its molecular epidemiological and genetic characteristics.BMC microbiology · 2026Article
- Molecular insights into the persistence and co-occurrence of two different carbapenem-resistantMicrobiology spectrum · 2025Article
- Genomic features and fitness cost of co-existence ofFrontiers in cellular and infection microbiology · 2025Article
- Emergence of carbapenem-resistantMicrobiology spectrum · 2024Article
- Replicon-Based Typing About IncG Plasmids and Molecular Characterization of Five IncG Plasmids Carrying Carbapenem Resistance GeneInfection and drug resistance · 2024Article
- Molecular Epidemiological Characteristics of Carbapenem ResistantInfection and drug resistance · 2024Article
- Emergence and clonal dissemination of KPC-3-producing Pseudomonas aeruginosa in China with an IncP-2 megaplasmid.Annals of clinical microbiology and antimicrobials · 2023Article
- Antimicrobial Resistance in Romania: Updates on Gram-Negative ESCAPE Pathogens in the Clinical, Veterinary, and Aquatic Sectors.International journal of molecular sciences · 2023Review
- Worldwide Dissemination ofAntibiotics (Basel, Switzerland) · 2023Review
- Emergence ofFrontiers in microbiology · 2023Article
- A Plasmid CarryingMicroorganisms · 2022Article
- Article
- Article
- Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-ProducingFrontiers in microbiology · 2022Article
- Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam.Journal of global antimicrobial resistance · 2021Article
- Genomic characterization of carbapenem-non-susceptibleEmerging microbes & infections · 2021Article
- Characterization ofAntibiotics (Basel, Switzerland) · 2021Article
- Draft Genome Sequence of aMicrobiology resource announcements · 2021Article
- Characterization of Emerging Pathogens CarryingFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Pseudomonas aeruginosa strain 10265 was recovered from a patient with pneumonia in a Chinese public hospital, and it displays the carbapenem resistance phenotype due to the acquisition of a non-conjugative but mobilizable IncP-6-type plasmid p10265-KPC. p10265-KPC carries a Tn5563-borne defective mer locus, and a novel ΔISEc33-associated bla KPC-2 gene cluster without paired inverted repeats and paired direct repeats at both ends. Mobilization of this ΔISEc33-associated element in p10265-KPC would be attributed to homologous recombination-based insertion of a foreign structure Tn3-ISApu1-orf7-ISApu2- ISKpn27-Δbla TEM-1 -bla KPC-2 -ΔISKpn6- korC-orf6-klcA-ΔrepB into a pre-existent intact ISEc33, making ISEc33 truncated at the 3' end. The previously reported pCOL-1 represents the first sequenced KPC-producing IncP-6 plasmid, while p10265-KPC is the second one. These two plasmids carry two distinct bla KPC-2 gene clusters, which are inserted into the different sites of the IncP-6 backbone and have different evolutionary histories of assembly and mobilization. This is the first report of identification of the IncP-6-type resistance plasmid in China.
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