ArticleFrontiers in physiology2016
Acute Response of Circulating Vascular Regulating MicroRNAs during and after High-Intensity and High-Volume Cycling in Children.
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Comparative effects of continuous glucose monitoring-informed and traditional interval-based carbohydrate refueling protocols on endurance exercise responses: an exploratory study.Journal of the International Society of Sports Nutrition · 2025Trial
- Small non-coding RNAs are altered by short-term sprint interval training in men.Physiological reports · 2018Trial
- miR-126: a bridge between cancer and exercise.Cancer cell international · 2025Review
- Regulating the expression of exercise-induced micro-RNAs and long non-coding RNAs: implications for controlling cardiovascular diseases and heart failure.Frontiers in molecular biosciences · 2025Review
- Effects of structured exercise training on miRNA expression in previously sedentary individuals.PloS one · 2024Article
- Roles of physical exercise-induced MiR-126 in cardiovascular health of type 2 diabetes.Diabetology & metabolic syndrome · 2022Review
- Targeting miR-21 in spinal cord injuries: a game-changer?Molecular medicine (Cambridge, Mass.) · 2022Review
- Changes in circulating microRNA and arterial stiffness following high-intensity interval and moderate intensity continuous exercise.Physiological reports · 2020Article
- High intensity interval training and molecular adaptive response of skeletal muscle.Sports medicine and health science · 2019Review
- The effects of moderate and high-intensity exercise on circulating markers of endothelial integrity and activation in young, healthy men.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Article
- Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- Importance of physical capacity and the effects of exercise in heart transplant recipients.World journal of transplantation · 2018Review
- Longer Work/Rest Intervals During High-Intensity Interval Training (HIIT) Lead to Elevated Levels of miR-222 and miR-29c.Frontiers in physiology · 2018Article
- Exercise-induced circulating microRNA changes in athletes in various training scenarios.PloS one · 2018Article
- Dose-Response of High-Intensity Training (HIT) on Atheroprotective miRNA-126 Levels.Frontiers in physiology · 2017Article
- Markers of biological stress in response to a single session of high-intensity interval training and high-volume training in young athletes.European journal of applied physiology · 2016Article
- Circulating MicroRNAs as Potential Biomarkers of Exercise Response.International journal of molecular sciences · 2016Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of the present study was to analyze the response of vascular circulating microRNAs (miRNAs; miR-16, miR-21, miR-126) and the VEGF mRNA following an acute bout of HIIT and HVT in children.
methodsTwelve healthy competitive young male cyclists (14.4 ± 0.8 years; 57.9 ± 9.4 ml·min(-1)·kg(-1) peak oxygen uptake) performed one session of high intensity 4 × 4 min intervals (HIIT) at 90-95% peak power output (PPO), each interval separated by 3 min of active recovery, and one high volume session (HVT) consisting of a constant load exercise for 90 min at 60% PPO. Capillary blood from the earlobe was collected under resting conditions, during exercise (d1 = 20 min, d2 = 30 min, d3 = 60 min), and 0, 30, 60, 180 min after the exercise to determine miR-16, -21, -126, and VEGF mRNA.
resultsHVT significantly increased miR-16 and miR-126 during and after the exercise compared to pre-values, whereas HIIT showed no significant influence on the miRNAs compared to pre-values. VEGF mRNA significantly increased during and after HIIT (d1, 30', 60', 180') and HVT (d3, 0', 60').
conclusionRESULTS of the present investigation suggest a volume dependent exercise regulation of vascular regulating miRNAs (miR-16, miR-21, miR-126) in children. In line with previous data, our data show that acute exercise can alter circulating miRNAs profiles that might be used as novel biomarkers to monitor acute and chronic changes due to exercise in various tissues.
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