ArticleFrontiers in human neuroscience2016
A Diamond-Based Electrode for Detection of Neurochemicals in the Human Brain.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01705301 (Neurotransmitter Measurements Using Wireless Instantaneous Neurotransmitter Concentration System), which is not on this map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurotransmitter Measurements Using Wireless Instantaneous Neurotransmitter Concentration System (WINCS) During Deep Brain Stimulation Neurosurgery.
Who cites it
55 citing papers in PubMed, 102 citations in OpenAlex.
- Boron-Doped Nano-Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing.Advanced healthcare materials · 2026Article
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- Thin-Film Reference Electrodes for Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2025Article
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Improved longevity andFrontiers in bioengineering and biotechnology · 2025Article
- Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications.Frontiers in bioengineering and biotechnology · 2025Review
- Evaluation of In Vitro Serotonin-Induced Electrochemical Fouling Performance of Boron Doped Diamond Microelectrode Using Fast-Scan Cyclic Voltammetry.Biosensors · 2024Article
- Understanding the different effects of fouling mechanisms on working and reference electrodes in fast-scan cyclic voltammetry for neurotransmitter detection.The Analyst · 2024Article
- Structural, Functional, and Genetic Changes Surrounding Electrodes Implanted in the Brain.Accounts of chemical research · 2024Article
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- Editors' Choice-Review-The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective.ECS sensors plus · 2023Review
- Exploring CVD Method for Synthesizing Carbon-Carbon Composites as Materials to Contact with Nerve Tissue.Journal of functional biomaterials · 2023Article
- In Vitro Biofouling Performance of Boron-Doped Diamond Microelectrodes for Serotonin Detection Using Fast-Scan Cyclic Voltammetry.Biosensors · 2023Article
- Fluorescence modulation of nanodiamond NVMRS advances · 2022Article
- MPCVD-Grown Nanodiamond Microelectrodes with Oxygen Plasma Activation for Neurochemical Applications.ACS sensors · 2022Article
- Letting the little light of mind shine: Advances and future directions in neurochemical detection.Neuroscience research · 2022Review
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- Review
- Perspective-Electrochemical Sensors for Neurotransmitters and Psychiatrics: Steps toward Physiological Mental Health Monitoring.Journal of the Electrochemical Society · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Deep brain stimulation (DBS), a surgical technique to treat certain neurologic and psychiatric conditions, relies on pre-determined stimulation parameters in an open-loop configuration. The major advancement in DBS devices is a closed-loop system that uses neurophysiologic feedback to dynamically adjust stimulation frequency and amplitude. Stimulation-driven neurochemical release can be measured by fast-scan cyclic voltammetry (FSCV), but existing FSCV electrodes rely on carbon fiber, which degrades quickly during use and is therefore unsuitable for chronic neurochemical recording. To address this issue, we developed durable, synthetic boron-doped diamond-based electrodes capable of measuring neurochemical release in humans. Compared to carbon fiber electrodes, they were more than two orders-of-magnitude more physically-robust and demonstrated longevity in vitro without deterioration. Applied for the first time in humans, diamond electrode recordings from thalamic targets in patients (n = 4) undergoing DBS for tremor produced signals consistent with adenosine release at a sensitivity comparable to carbon fiber electrodes. (Clinical trials # NCT01705301).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.