ArticleFrontiers in neuroscience2016
Boron-Doped Nanocrystalline Diamond Electrodes for Neural Interfaces: In vivo Biocompatibility Evaluation.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Electrical Stimulation of Cells: Drivers, Technology, and Effects.Chemical reviews · 2025Review
- Nitrogen-Doped Ultrananocrystalline Diamond - Optoelectronic Biointerface for Wireless Neuronal Stimulation.Advanced healthcare materials · 2025Article
- Advances in Spinal Cord Stimulation.Bioengineering (Basel, Switzerland) · 2023Review
- Microdialysis and microperfusion electrodes in neurologic disease monitoring.Fluids and barriers of the CNS · 2021Review
- Biocompatible reference electrodes to enhance chronic electrochemical signal fidelity in vivo.Analytical and bioanalytical chemistry · 2021Review
- Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.Micromachines · 2021Review
- Recent advances in neural interfaces-Materials chemistry to clinical translation.MRS bulletin · 2020Article
- A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants.Frontiers in bioengineering and biotechnology · 2020Review
- Quantal Release of Dopamine and Action Potential Firing Detected in Midbrain Neurons by Multifunctional Diamond-Based Microarrays.Frontiers in neuroscience · 2019Article
- A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro.Scientific reports · 2018Article
- Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization.Acta biomaterialia · 2018Article
- Diamond/Porous Titanium Nitride Electrodes With Superior Electrochemical Performance for Neural Interfacing.Frontiers in bioengineering and biotechnology · 2018Article
- Diamond thin films: giving biomedical applications a new shine.Journal of the Royal Society, Interface · 2017Review
- Invasive Intraneural Interfaces: Foreign Body Reaction Issues.Frontiers in neuroscience · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Boron-doped nanocrystalline diamond (BDD) electrodes have recently attracted attention as materials for neural electrodes due to their superior physical and electrochemical properties, however their biocompatibility remains largely unexplored. In this work, we aim to investigate the in vivo biocompatibility of BDD electrodes in relation to conventional titanium nitride (TiN) electrodes using a rat subcutaneous implantation model. High quality BDD films were synthesized on electrodes intended for use as an implantable neurostimulation device. After implantation for 2 and 4 weeks, tissue sections adjacent to the electrodes were obtained for histological analysis. Both types of implants were contained in a thin fibrous encapsulation layer, the thickness of which decreased with time. Although the level of neovascularization around the implants was similar, BDD electrodes elicited significantly thinner fibrous capsules and a milder inflammatory reaction at both time points. These results suggest that BDD films may constitute an appropriate material to support stable performance of implantable neural electrodes over time.
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