ArticleFrontiers in neuroscience2016
Influence of Corticospinal Tracts from Higher Order Motor Cortices on Recruitment Curve Properties in Stroke.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- MEP Status is Not Predictive of Response to Upper Limb Training in People With Chronic, Moderate-Severe Hemiparesis Post-Stroke.Neurorehabilitation and neural repair · 2025Trial
- Effect of transcranial direct current stimulation on post-stroke fatigue.Journal of neurology · 2021Trial
- Inhibition versus facilitation of contralesional motor cortices in stroke: Deriving a model to tailor brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Trial
- Age-related differences in agility are related to both muscle strength and corticospinal tract function.Physiological reports · 2025Article
- Water and brain function: effects of hydration status on neurostimulation with transcranial magnetic stimulation.Journal of neurophysiology · 2024Article
- Changes in brain functional connectivity and muscle strength independent of elbow flexor atrophy following upper limb immobilization in young females.Experimental physiology · 2024Article
- Corticospinal tract: a new hope for the treatment of post-stroke spasticity.Acta neurologica Belgica · 2024Review
- Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis.IBRO neuroscience reports · 2023Article
- Can training of a skilled pelvic movement change corticomotor control of back muscles? Comparison of single and paired-pulse transcranial magnetic stimulation.The European journal of neuroscience · 2022Article
- Stimulation of frontal pathways disrupts hand muscle control during object manipulation.Brain : a journal of neurology · 2022Article
- Relationship Between Cortical Excitability Changes and Cortical Thickness in Subcortical Chronic Stroke.Frontiers in neurology · 2022Article
- A novel perspective of associativity of upper limb motor impairment and cortical excitability in sub-acute and chronic stroke.Frontiers in neuroscience · 2022Article
- Upper Limbs Muscle Co-contraction Changes Correlated With the Impairment of the Corticospinal Tract in Stroke Survivors: Preliminary Evidence From Electromyography and Motor-Evoked Potential.Frontiers in neuroscience · 2022Article
- Input-output slope curve estimation in neural stimulation based on optimal sampling principlesJournal of neural engineering · 2021Article
- Probing the Brain-Body Connection Using Transcranial Magnetic Stimulation (TMS): Validating a Promising Tool to Provide Biomarkers of Neuroplasticity and Central Nervous System Function.Brain sciences · 2021Article
- Strengthened structure-function relationships of the corticospinal tract by free water correction after stroke.Brain communications · 2021Article
- Stratifying chronic stroke patients based on the influence of contralesional motor cortices: An inter-hemispheric inhibition study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Transcranial magnetic stimulation reveals diminished homoeostatic metaplasticity in cognitively impaired adults.Brain communications · 2020Article
- Motor Point Stimulation in Spinal Paired Associative Stimulation can Facilitate Spinal Cord Excitability.Frontiers in human neuroscience · 2020Article
- Walking Training Enhances Corticospinal Excitability in Progressive Multiple Sclerosis-A Pilot Study.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRecruitment curves (RCs) acquired using transcranial magnetic stimulation are commonly used in stroke to study physiologic functioning of corticospinal tracts (CST) from M1. However, it is unclear whether CSTs from higher motor cortices contribute as well.
objectiveTo explore whether integrity of CST from higher motor areas, besides M1, relates to CST functioning captured using RCs.
methodsRCs were acquired for a paretic hand muscle in patients with chronic stroke. Metrics describing gain and overall output of CST were collected. CST integrity was defined by diffusion tensor imaging. For CST emerging from M1 and higher motor areas, integrity (fractional anisotropy) was evaluated in the region of the posterior limb of the internal capsule, the length of CST and in the region of the stroke lesion.
resultsWe found that output and gain of RC was related to integrity along the length of CST emerging from higher motor cortices but not the M1.
conclusionsOur results suggest that RC parameters in chronic stroke infer function primarily of CST descending from the higher motor areas but not M1. RCs may thus serve as a simple, in-expensive means to assess re-mapping of alternate areas that is generally studied with resource-intensive neuroimaging in stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.