ArticleJournal of clinical biochemistry and nutrition2016
Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia.
Article in Journal of clinical biochemistry and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Wearable-Based Monitoring of Autonomic and Gastrointestinal Function in Disorders of Gut-Brain Interaction: A Systematic Review and Meta-Analyses.Neurogastroenterology and motility · 2026Pooled it
- DA-9701 for Gastrointestinal Symptoms in Postural Orthostatic Tachycardia Syndrome: A Randomized Pilot Study.Journal of neurogastroenterology and motility · 2026Article
- Diagnosis of Functional Dyspepsia and Novel Gastrointestinal Functional Assessments.Digestion · 2026Review
- Analysis of autonomic function in patients with functional dyspepsia using real-time wearable devices and smartphone applications.Journal of clinical biochemistry and nutrition · 2025Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Disturbances of autonomic nervous system and gastric activity in response to visceral stimulation in functional dyspepsia patients.Przeglad gastroenterologiczny · 2025Article
- Stress Response Pattern of Heart Rate Variability in Patients with Functional Somatic Syndromes.Applied psychophysiology and biofeedback · 2024Article
- Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review.Foods (Basel, Switzerland) · 2024Review
- Roles of Heart Rate Variability in Assessing Autonomic Nervous System in Functional Gastrointestinal Disorders: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Spinal cord stimulation-induced gastroparesis: A case report.Surgical neurology international · 2023Article
- State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities.Journal of clinical biochemistry and nutrition · 2022Article
- The autonomic nervous system: A potential link to the efficacy of acupuncture.Frontiers in neuroscience · 2022Review
- Association between dyspeptic symptoms and endoscopic findings based on the Kyoto classification of gastritis in Japanese male.Journal of clinical biochemistry and nutrition · 2022Article
- A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection.Headache · 2021Review
- Upregulation of gastric norepinephrine with beta-adrenoceptors and gastric dysmotility in a rat model of functional dyspepsia.Physiological research · 2020Article
- 'New/Designer Benzodiazepines': An Analysis of the Literature and Psychonauts' Trip Reports.Current neuropharmacology · 2020Review
- Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects.Internal medicine (Tokyo, Japan) · 2019Article
- Impaired vagal activity to meal in patients with functional dyspepsia and delayed gastric emptying.The Journal of international medical research · 2018Article
- Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography.Journal of clinical biochemistry and nutrition · 2017Article
- Increase of transient lower esophageal sphincter relaxation associated with cascade stomach.Journal of clinical biochemistry and nutrition · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the role of autonomic nervous system in functional dyspepsia patients, we examined 24-h heart rate variability: the basal levels, responses after lunch, cold pressor and mental arithmetic tests, and the efficacy of an autonomic drug (tofisopam). The high-frequency component (HF: 0.15-0.40 Hz) and the ratio of HF to the low-frequency component (LF: 0.04-0.15 Hz; LF/HF ratio) were used as indicators of parasympathetic and sympathetic autonomic nervous system function. The HF component in the 24-h, daytime, and nighttime was low in 86.7%, 97.8%, and 66.7% of patients (n = 45) and the LF/HF ratio was high in 51.1%, 73.3%, and 26.6% of patients. Gastrointestinal symptom tended to be severe in patients with autonomic nervous system disorder (p = 0.085). The abnormal response in HF component after lunch occurred in 38.2% (13/34) of patients who revealed a greater tendency towards in indigestion score (p = 0.061). Delays in recovery to the basal autonomic nervous system level after stimulus of the cold pressor and the mental arithmetic tests occurred in parts of patients. Tofisopam partially improved autonomic nervous system dysfunction and abdominal pain/indigestion. Imbalanced autonomic nervous system function and vulnerability for recovery from external stimuli were observed in functional dyspepsia patients, which was associated with dyspeptic symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.